Abstract
The p53 tumor suppressor gene and gene product are among the most diverse and complex molecules involved in cellular functions. Genetic alterations within the p53 gene have been shown to have a direct correlation with cancer development and have been shown to occur in nearly 50% of all cancers. p53 mutations are particularly common in skin cancers and UV irradiation has been shown to be a primary cause of specific' signature' mutations that can result in oncogenic transformatiorn. There are certain 'hot-spots' in the p53 gene where mutations are commonly found that result in a mutated dipyrimidine site. This review discusses the role of p53 from normal function and its dysfunction in precancerous lesions, nonmelanoma and melanoma skin cancers. Additionally, molecules that associate with p53 and alter its function to produce neoplastic conditions are also explored in this chapter.
| Original language | English |
|---|---|
| Pages (from-to) | 265-282 |
| Number of pages | 18 |
| Journal | Advances in Experimental Medicine and Biology |
| Volume | 624 |
| DOIs | |
| State | Published - Dec 1 2008 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
- Medicine(all)
Cite this
P53 protein and pathogenesis of melanoma and nonmelanoma skin cancer. / Ananthaswamy, Honnavara N.; Benjamin, Cara; Melnikova, Vladislava O.
In: Advances in Experimental Medicine and Biology, Vol. 624, 01.12.2008, p. 265-282.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - P53 protein and pathogenesis of melanoma and nonmelanoma skin cancer
AU - Ananthaswamy, Honnavara N.
AU - Benjamin, Cara
AU - Melnikova, Vladislava O.
PY - 2008/12/1
Y1 - 2008/12/1
N2 - The p53 tumor suppressor gene and gene product are among the most diverse and complex molecules involved in cellular functions. Genetic alterations within the p53 gene have been shown to have a direct correlation with cancer development and have been shown to occur in nearly 50% of all cancers. p53 mutations are particularly common in skin cancers and UV irradiation has been shown to be a primary cause of specific' signature' mutations that can result in oncogenic transformatiorn. There are certain 'hot-spots' in the p53 gene where mutations are commonly found that result in a mutated dipyrimidine site. This review discusses the role of p53 from normal function and its dysfunction in precancerous lesions, nonmelanoma and melanoma skin cancers. Additionally, molecules that associate with p53 and alter its function to produce neoplastic conditions are also explored in this chapter.
AB - The p53 tumor suppressor gene and gene product are among the most diverse and complex molecules involved in cellular functions. Genetic alterations within the p53 gene have been shown to have a direct correlation with cancer development and have been shown to occur in nearly 50% of all cancers. p53 mutations are particularly common in skin cancers and UV irradiation has been shown to be a primary cause of specific' signature' mutations that can result in oncogenic transformatiorn. There are certain 'hot-spots' in the p53 gene where mutations are commonly found that result in a mutated dipyrimidine site. This review discusses the role of p53 from normal function and its dysfunction in precancerous lesions, nonmelanoma and melanoma skin cancers. Additionally, molecules that associate with p53 and alter its function to produce neoplastic conditions are also explored in this chapter.
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UR - http://www.scopus.com/inward/citedby.url?scp=42949177519&partnerID=8YFLogxK
U2 - 10.1007/978-0-387-77574-6_21
DO - 10.1007/978-0-387-77574-6_21
M3 - Article
C2 - 18348463
AN - SCOPUS:42949177519
VL - 624
SP - 265
EP - 282
JO - Advances in Experimental Medicine and Biology
JF - Advances in Experimental Medicine and Biology
SN - 0065-2598
ER -