P53, GHRH, inflammation and cancer

Nektarios Barabutis, Andrew V. Schally, Agnieszka Siejka

Research output: Contribution to journalReview article

29 Scopus citations

Abstract

P53 is a transcription factor very often mutated in malignancies. It functions towards the regulation of important cellular activities, such as cell cycle, senescence and apoptosis. Since inflammation and cancer are strongly associated through common pathways, P53 can suppress inflammation in a plethora of human tissues. Growth Hormone - Releasing Hormone is a hypothalamic peptide with a great capacity to affect the complex networks of cellular regulation via GHRH - specific receptors. GHRH antagonistic and agonistic analogs have been developed for clinical applications, including treatment of benign prostatic hyperplasia, breast, prostate and lung cancers, diabetes and neurodegenerative diseases. The epicenter of the current manuscript is the protective role of P53 against inflammation and cancer and emphasizes the p53 – mediated beneficial effects of GHRH antagonists in various human diseases.

Original languageEnglish (US)
Pages (from-to)557-562
Number of pages6
JournalEBioMedicine
Volume37
DOIs
StatePublished - Nov 2018

Keywords

  • Barrier function
  • Growth factors
  • Oncology

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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