P53 family: Role of protein isoforms in human cancer

Jinxiong Wei, Elena Zaika, Alexander Zaika

Research output: Contribution to journalReview articlepeer-review

66 Scopus citations

Abstract

TP53, TP63, and TP73 genes comprise the p53 family. Each gene produces protein isoforms through multiple mechanisms including extensive alternative mRNA splicing. Accumulating evidence shows that these isoforms play a critical role in the regulation of many biological processes in normal cells. Their abnormal expression contributes to tumorigenesis and has a profound effect on tumor response to curative therapy. This paper is an overview of isoform diversity in the p53 family and its role in cancer.

Original languageEnglish (US)
Article number687359
JournalJournal of Nucleic Acids
Volume2012
DOIs
StatePublished - 2012

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology

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