P53-dependent transcriptional regulation of EDA2R and its involvement in chemotherapy-induced hair loss

Ran Brosh, Rachel Sarig, Elad Bar Natan, Alina Molchadsky, Shalom Madar, Chamutal Bornstein, Yosef Buganim, Tirosh Shapira, Naomi Goldfinger, Ralf Paus, Varda Rotter

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

The p53 tumor suppressor coordinates a multitude of cellular and organismal processes and exerts its activities mainly by activation of gene transcription. Here we describe the transcriptional activation of ectodysplasin A2 receptor (EDA2R) by p53 in a variety of cell types and tissues. We demonstrate that treatment of cancer cells with the ligand EDA-A2, known to specifically activate EDA2R, results in p53-dependent cell death. Moreover, we show that EDA2R is transactivated by p53 during chemotherapy-induced hair-loss, although its presence is not necessary for this process. These data shed new light on the role of EDA2R in exerting p53 function.

Original languageEnglish (US)
Pages (from-to)2473-2477
Number of pages5
JournalFEBS Letters
Volume584
Issue number11
DOIs
StatePublished - Jun 1 2010
Externally publishedYes

Fingerprint

Xedar Receptor
Chemotherapy
Alopecia
Transcriptional Activation
Drug Therapy
Chemical activation
Cell death
Transcription
varespladib methyl
Tumors
Neoplasms
Cell Death
Genes
Cells
Tissue
Ligands

Keywords

  • Alopecia
  • Chemotherapy-induced alopecia
  • Cyclophosphamide
  • Knockout
  • XEDAR

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

Cite this

Brosh, R., Sarig, R., Natan, E. B., Molchadsky, A., Madar, S., Bornstein, C., ... Rotter, V. (2010). P53-dependent transcriptional regulation of EDA2R and its involvement in chemotherapy-induced hair loss. FEBS Letters, 584(11), 2473-2477. https://doi.org/10.1016/j.febslet.2010.04.058

P53-dependent transcriptional regulation of EDA2R and its involvement in chemotherapy-induced hair loss. / Brosh, Ran; Sarig, Rachel; Natan, Elad Bar; Molchadsky, Alina; Madar, Shalom; Bornstein, Chamutal; Buganim, Yosef; Shapira, Tirosh; Goldfinger, Naomi; Paus, Ralf; Rotter, Varda.

In: FEBS Letters, Vol. 584, No. 11, 01.06.2010, p. 2473-2477.

Research output: Contribution to journalArticle

Brosh, R, Sarig, R, Natan, EB, Molchadsky, A, Madar, S, Bornstein, C, Buganim, Y, Shapira, T, Goldfinger, N, Paus, R & Rotter, V 2010, 'P53-dependent transcriptional regulation of EDA2R and its involvement in chemotherapy-induced hair loss', FEBS Letters, vol. 584, no. 11, pp. 2473-2477. https://doi.org/10.1016/j.febslet.2010.04.058
Brosh, Ran ; Sarig, Rachel ; Natan, Elad Bar ; Molchadsky, Alina ; Madar, Shalom ; Bornstein, Chamutal ; Buganim, Yosef ; Shapira, Tirosh ; Goldfinger, Naomi ; Paus, Ralf ; Rotter, Varda. / P53-dependent transcriptional regulation of EDA2R and its involvement in chemotherapy-induced hair loss. In: FEBS Letters. 2010 ; Vol. 584, No. 11. pp. 2473-2477.
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