p53 and the pathogenesis of skin cancer

Cara Benjamin, Honnavara N. Ananthaswamy

Research output: Contribution to journalArticle

78 Citations (Scopus)

Abstract

The p53 tumor suppressor gene and gene product are among the most diverse and complex molecules involved in cellular functions. Genetic alterations within the p53 gene have been shown to have a direct correlation with cancer development and have been shown to occur in nearly 50% of all cancers. p53 mutations are particularly common in skin cancers and UV irradiation has been shown to be a primary cause of specific 'signature' mutations that can result in oncogenic transformation. There are certain 'hot-spots' in the p53 gene where mutations are commonly found that result in a mutated dipyrimidine site. This review discusses the role of p53 from normal function and its dysfunction in pre-cancerous lesions and non-melanoma skin cancers. Additionally, special situations are explored, such as Li-Fraumeni syndrome in which there is an inherited p53 mutation, and the consequences of immune suppression on p53 mutations and the resulting increase in non-melanoma skin cancer in these patients.

Original languageEnglish
Pages (from-to)241-248
Number of pages8
JournalToxicology and Applied Pharmacology
Volume224
Issue number3
DOIs
StatePublished - Nov 1 2007
Externally publishedYes

Fingerprint

Skin Neoplasms
Skin
Genes
Mutation
p53 Genes
Li-Fraumeni Syndrome
Tumors
Tumor Suppressor Genes
Irradiation
Neoplasms
Molecules

Keywords

  • Non-melanoma skin cancer
  • p53
  • UV irradiation

ASJC Scopus subject areas

  • Pharmacology
  • Toxicology

Cite this

p53 and the pathogenesis of skin cancer. / Benjamin, Cara; Ananthaswamy, Honnavara N.

In: Toxicology and Applied Pharmacology, Vol. 224, No. 3, 01.11.2007, p. 241-248.

Research output: Contribution to journalArticle

Benjamin, Cara ; Ananthaswamy, Honnavara N. / p53 and the pathogenesis of skin cancer. In: Toxicology and Applied Pharmacology. 2007 ; Vol. 224, No. 3. pp. 241-248.
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