P27 expression in post-treatment rectal cancer: A potential novel approach for predicting residual nodal disease

Tobias Leibold, Vanessa W. Hui, Jinru Shia, Jeannine A. Ruby, Elyn R. Riedel, José G. Guillem

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Background Expression profiles of p21, p27, p53, Ki-67, and thymidylate synthase may be associated with response to neoadjuvant chemoradiation. The relationship between post-treatment protein expression and regional lymph node involvement has not been fully explored. Methods Tumor cores from 126 rectal cancer patients underwent immunohistochemical analysis for the aforementioned proteins. Staining indices (SIs) using percentage of stained cells and staining intensity were calculated for 10 tumor cores per patient. SI for each marker was compared between node negative and node positive patients. Results Twenty-six (20.6%) cancer patients had a pathologic complete response and 37 had inadequate tissue or cancer cells, leaving 63 for analysis. Thirty-seven (58.7%) cancer patients were node negative and 26 (41.3%) were node positive. There was an association between increased p27 SI and nodal positivity (P =.04). Conclusion Increased p27 expression in post-treatment rectal cancer is associated with nodal positivity and may determine which patients are suitable for local excision.

Original languageEnglish (US)
Pages (from-to)228-234
Number of pages7
JournalAmerican journal of surgery
Volume208
Issue number2
DOIs
StatePublished - Aug 2014
Externally publishedYes

Keywords

  • Lymph node positivity
  • Molecular marker
  • Post-treatment rectal cancer
  • Tissue microarray

ASJC Scopus subject areas

  • Surgery

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