p27: A barometer of signaling deregulation and potential predictor of response to targeted therapies

Seth A. Wander; Dekuang Zhao; Joyce M. Slingerland

doi:10.1158/1078-0432.CCR-10-0752

p27: A barometer of signaling deregulation and potential predictor of response to targeted therapies

Seth A. Wander, Dekuang Zhao, Joyce M. Slingerland

Medicine

Research output: Contribution to journal › Article › peer-review

118 Scopus citations

Abstract

Phosphorylation of the cyclin-dependent kinase inhibitor p27 by upstream mitogenic signaling pathways regulates its stability, localization, and biological function. In human cancers, loss of the antiproliferative action of p27 can arise through reduced protein levels and/or cytoplasmic mislocalization, leading to increased cell proliferation and/or cell migration, respectively. Reduced p27 expression levels and p27 mislocalization have potential prognostic and therapeutic implications in various types of human cancers. This review highlights mechanisms of functional deregulation of p27 by oncogenic signaling that provide an important molecular rationale for pathway targeting in cancer treatment.

Original language	English (US)
Pages (from-to)	12-18
Number of pages	7
Journal	Clinical Cancer Research
Volume	17
Issue number	1
DOIs	https://doi.org/10.1158/1078-0432.CCR-10-0752
State	Published - Jan 1 2011

ASJC Scopus subject areas

Oncology
Cancer Research

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abstract = "Phosphorylation of the cyclin-dependent kinase inhibitor p27 by upstream mitogenic signaling pathways regulates its stability, localization, and biological function. In human cancers, loss of the antiproliferative action of p27 can arise through reduced protein levels and/or cytoplasmic mislocalization, leading to increased cell proliferation and/or cell migration, respectively. Reduced p27 expression levels and p27 mislocalization have potential prognostic and therapeutic implications in various types of human cancers. This review highlights mechanisms of functional deregulation of p27 by oncogenic signaling that provide an important molecular rationale for pathway targeting in cancer treatment.",

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