TY - JOUR
T1 - p27
T2 - A barometer of signaling deregulation and potential predictor of response to targeted therapies
AU - Wander, Seth A.
AU - Zhao, Dekuang
AU - Slingerland, Joyce M.
PY - 2011/1/1
Y1 - 2011/1/1
N2 - Phosphorylation of the cyclin-dependent kinase inhibitor p27 by upstream mitogenic signaling pathways regulates its stability, localization, and biological function. In human cancers, loss of the antiproliferative action of p27 can arise through reduced protein levels and/or cytoplasmic mislocalization, leading to increased cell proliferation and/or cell migration, respectively. Reduced p27 expression levels and p27 mislocalization have potential prognostic and therapeutic implications in various types of human cancers. This review highlights mechanisms of functional deregulation of p27 by oncogenic signaling that provide an important molecular rationale for pathway targeting in cancer treatment.
AB - Phosphorylation of the cyclin-dependent kinase inhibitor p27 by upstream mitogenic signaling pathways regulates its stability, localization, and biological function. In human cancers, loss of the antiproliferative action of p27 can arise through reduced protein levels and/or cytoplasmic mislocalization, leading to increased cell proliferation and/or cell migration, respectively. Reduced p27 expression levels and p27 mislocalization have potential prognostic and therapeutic implications in various types of human cancers. This review highlights mechanisms of functional deregulation of p27 by oncogenic signaling that provide an important molecular rationale for pathway targeting in cancer treatment.
UR - http://www.scopus.com/inward/record.url?scp=78751505998&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=78751505998&partnerID=8YFLogxK
U2 - 10.1158/1078-0432.CCR-10-0752
DO - 10.1158/1078-0432.CCR-10-0752
M3 - Article
C2 - 20966355
AN - SCOPUS:78751505998
VL - 17
SP - 12
EP - 18
JO - Clinical Cancer Research
JF - Clinical Cancer Research
SN - 1078-0432
IS - 1
ER -