Ozone-induced tolerance to hyperoxia in rats

R. M. Jackson, L. Frank

Research output: Contribution to journalArticlepeer-review

40 Scopus citations


Preexposure of adult rats to ozone (0.8 ± 0.1 ppm for 7 days) has been found to produce a marked degree of tolerance to hyperoxia (greater than 95% O2). The survival of O3-preexposed rats in hyperoxia for 168 h was 28 of 32 (88%) compared with a rate of 2 of 18 (11%) for nonpreexposed rats. Total lung superoxide dismutase (SOD), glutathione peroxidase (GP), glucose-6-phosphate dehydrogenase (G6-PD), and catalase (CAT) activities were alll significantly increased after O3 preexposure and after the subsequent hyperoxic challenge. Probable mechanisms accounting for the markedly improved survival in hyperoxia after O3 preexposure include both increased lung antioxidant enzyme activities and repair of structural damage by proliferation of alveolar lining cells. The demonstration of cross-tolerance between the atmospheric oxidants O3 and O2 suggests that there are similarities in the lung's adaptation to both oxidants.

Original languageEnglish (US)
Pages (from-to)425-429
Number of pages5
JournalAmerican Review of Respiratory Disease
Issue number3
StatePublished - 1984
Externally publishedYes

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine


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