Oxygen-sensitive 19F NMR imaging of the vascular system in vivo

Joel E. Fishman, Peter M. Joseph, Thomas F. Floyd, Biswanath Mukherji, Henry A. Sloviter

Research output: Contribution to journalArticle

52 Scopus citations

Abstract

The fluorine nuclear magnetic resonance spin-lattice relaxation rate ( 1 T1) of the perfluorochemical blood substitute perfluorotripropylamine (FTPA) is very sensitive to oxygen tension. This presents the possibility of measuring blood oxygen tension by 19F MR imaging. We obtained oxygen-sensitive 19F NMR images of the circulatory system of rats infused with emulsified FTPA. Blood oxygenation was assessed under conditions of both air- and 100% O2-breathing. T1 relaxation times were derived from MR images using a partial saturation pulse sequence. The T1 times were compared with a phantom calibration curve to calculate average blood pO2 values in the lung, liver, and spleen. The results showed marked, organ-specific increases in blood oxygen tension when the rat breathed 100% O2 instead of air.

Original languageEnglish (US)
Pages (from-to)279-285
Number of pages7
JournalMagnetic Resonance Imaging
Volume5
Issue number4
DOIs
StatePublished - 1987
Externally publishedYes

Keywords

  • Blood oxygenation
  • Cardiovascular MR imaging
  • Fluorine NMR
  • Fluorocarbons
  • T measurement

ASJC Scopus subject areas

  • Biophysics
  • Clinical Biochemistry
  • Structural Biology
  • Radiology Nuclear Medicine and imaging
  • Condensed Matter Physics

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