Oxygen producing biomaterials for tissue regeneration

Benjamin S. Harrison, Daniel Eberli, Sang Jin Lee, Anthony Atala, James J. Yoo

Research output: Contribution to journalArticle

116 Citations (Scopus)

Abstract

A limiting factor in regenerating large organs and healing large wounds completely is the inability to provide oxygen to the affected areas for vascularization and healing to occur. An oxygen rich compound of sodium percarbonate was incorporated into films of Poly(d,l-lactide-co-glycolide) (PLGA) and used for in situ production of oxygen. Oxygen release could be observed from the film over a period of 24 h. When the oxygen producing biomaterials were placed in contact with ischemic tissue in a mouse model, decreased tissue necrosis and cellular apoptosis was observed. This indicates that improved tissue viability could be maintained for several days using oxygen producing biomaterials.

Original languageEnglish
Pages (from-to)4628-4634
Number of pages7
JournalBiomaterials
Volume28
Issue number31
DOIs
StatePublished - Nov 1 2007
Externally publishedYes

Fingerprint

Tissue regeneration
Biocompatible Materials
Biomaterials
Regeneration
Oxygen
Tissue
Oxygen Compounds
Tissue Survival
Wound Healing
Cell death
Necrosis
Apoptosis
Sodium

Keywords

  • Controlled drug release
  • Fibroblasts
  • Hypoxia
  • Oxygenation
  • Tissue engineering

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Biomedical Engineering

Cite this

Harrison, B. S., Eberli, D., Lee, S. J., Atala, A., & Yoo, J. J. (2007). Oxygen producing biomaterials for tissue regeneration. Biomaterials, 28(31), 4628-4634. https://doi.org/10.1016/j.biomaterials.2007.07.003

Oxygen producing biomaterials for tissue regeneration. / Harrison, Benjamin S.; Eberli, Daniel; Lee, Sang Jin; Atala, Anthony; Yoo, James J.

In: Biomaterials, Vol. 28, No. 31, 01.11.2007, p. 4628-4634.

Research output: Contribution to journalArticle

Harrison, BS, Eberli, D, Lee, SJ, Atala, A & Yoo, JJ 2007, 'Oxygen producing biomaterials for tissue regeneration', Biomaterials, vol. 28, no. 31, pp. 4628-4634. https://doi.org/10.1016/j.biomaterials.2007.07.003
Harrison BS, Eberli D, Lee SJ, Atala A, Yoo JJ. Oxygen producing biomaterials for tissue regeneration. Biomaterials. 2007 Nov 1;28(31):4628-4634. https://doi.org/10.1016/j.biomaterials.2007.07.003
Harrison, Benjamin S. ; Eberli, Daniel ; Lee, Sang Jin ; Atala, Anthony ; Yoo, James J. / Oxygen producing biomaterials for tissue regeneration. In: Biomaterials. 2007 ; Vol. 28, No. 31. pp. 4628-4634.
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