Abstract
The incorporation and oxidative sensitive release of doxorubicin (DOX), a hydrophobic model drug widely used as a chemotherapeutic agent in cancer therapy, were demonstrated. Particles with mean diameters of 100nm were obtained by polymerizing poly(propylene sulfide) (PPS) in emulsion employing Pluronic F-127 as the only surfactant. Exposure of particles to H2O 2 led to a faster release, with 46% of loaded DOX released after 300h and simultaneous swelling and degradation of the particles. The absence of H2O2 release was assumed to occur by slow protonation of DOX at the Pluronic-PPS-hydrophilic-hydrophobic interface.
| Original language | English |
|---|---|
| Title of host publication | Transactions - 7th World Biomaterials Congress |
| State | Published - Dec 1 2004 |
| Externally published | Yes |
| Event | Transactions - 7th World Biomaterials Congress - Sydney, Australia Duration: May 17 2004 → May 21 2004 |
Other
| Other | Transactions - 7th World Biomaterials Congress |
|---|---|
| Country | Australia |
| City | Sydney |
| Period | 5/17/04 → 5/21/04 |
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ASJC Scopus subject areas
- Engineering(all)
Cite this
Oxidative triggered release of doxorubicin from poly(sulfide) nanoparticles. / Rehor, A.; Tirelli, N.; Hubbell, J. A.
Transactions - 7th World Biomaterials Congress. 2004.Research output: Chapter in Book/Report/Conference proceeding › Conference contribution
}
TY - GEN
T1 - Oxidative triggered release of doxorubicin from poly(sulfide) nanoparticles
AU - Rehor, A.
AU - Tirelli, N.
AU - Hubbell, J. A.
PY - 2004/12/1
Y1 - 2004/12/1
N2 - The incorporation and oxidative sensitive release of doxorubicin (DOX), a hydrophobic model drug widely used as a chemotherapeutic agent in cancer therapy, were demonstrated. Particles with mean diameters of 100nm were obtained by polymerizing poly(propylene sulfide) (PPS) in emulsion employing Pluronic F-127 as the only surfactant. Exposure of particles to H2O 2 led to a faster release, with 46% of loaded DOX released after 300h and simultaneous swelling and degradation of the particles. The absence of H2O2 release was assumed to occur by slow protonation of DOX at the Pluronic-PPS-hydrophilic-hydrophobic interface.
AB - The incorporation and oxidative sensitive release of doxorubicin (DOX), a hydrophobic model drug widely used as a chemotherapeutic agent in cancer therapy, were demonstrated. Particles with mean diameters of 100nm were obtained by polymerizing poly(propylene sulfide) (PPS) in emulsion employing Pluronic F-127 as the only surfactant. Exposure of particles to H2O 2 led to a faster release, with 46% of loaded DOX released after 300h and simultaneous swelling and degradation of the particles. The absence of H2O2 release was assumed to occur by slow protonation of DOX at the Pluronic-PPS-hydrophilic-hydrophobic interface.
UR - http://www.scopus.com/inward/record.url?scp=13844296951&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=13844296951&partnerID=8YFLogxK
M3 - Conference contribution
SN - 1877040193
SN - 9781877040191
BT - Transactions - 7th World Biomaterials Congress
ER -