TY - GEN
T1 - Oxidative triggered release of doxorubicin from poly(sulfide) nanoparticles
AU - Rehor, A.
AU - Tirelli, N.
AU - Hubbell, J. A.
PY - 2004/12/1
Y1 - 2004/12/1
N2 - The incorporation and oxidative sensitive release of doxorubicin (DOX), a hydrophobic model drug widely used as a chemotherapeutic agent in cancer therapy, were demonstrated. Particles with mean diameters of 100nm were obtained by polymerizing poly(propylene sulfide) (PPS) in emulsion employing Pluronic F-127 as the only surfactant. Exposure of particles to H2O 2 led to a faster release, with 46% of loaded DOX released after 300h and simultaneous swelling and degradation of the particles. The absence of H2O2 release was assumed to occur by slow protonation of DOX at the Pluronic-PPS-hydrophilic-hydrophobic interface.
AB - The incorporation and oxidative sensitive release of doxorubicin (DOX), a hydrophobic model drug widely used as a chemotherapeutic agent in cancer therapy, were demonstrated. Particles with mean diameters of 100nm were obtained by polymerizing poly(propylene sulfide) (PPS) in emulsion employing Pluronic F-127 as the only surfactant. Exposure of particles to H2O 2 led to a faster release, with 46% of loaded DOX released after 300h and simultaneous swelling and degradation of the particles. The absence of H2O2 release was assumed to occur by slow protonation of DOX at the Pluronic-PPS-hydrophilic-hydrophobic interface.
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M3 - Conference contribution
AN - SCOPUS:13844296951
SN - 1877040193
SN - 9781877040191
T3 - Transactions - 7th World Biomaterials Congress
BT - Transactions - 7th World Biomaterials Congress
T2 - Transactions - 7th World Biomaterials Congress
Y2 - 17 May 2004 through 21 May 2004
ER -
