Oxidative triggered release of doxorubicin from poly(sulfide) nanoparticles

A. Rehor, N. Tirelli, J. A. Hubbell

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The incorporation and oxidative sensitive release of doxorubicin (DOX), a hydrophobic model drug widely used as a chemotherapeutic agent in cancer therapy, were demonstrated. Particles with mean diameters of 100nm were obtained by polymerizing poly(propylene sulfide) (PPS) in emulsion employing Pluronic F-127 as the only surfactant. Exposure of particles to H2O 2 led to a faster release, with 46% of loaded DOX released after 300h and simultaneous swelling and degradation of the particles. The absence of H2O2 release was assumed to occur by slow protonation of DOX at the Pluronic-PPS-hydrophilic-hydrophobic interface.

Original languageEnglish (US)
Title of host publicationTransactions - 7th World Biomaterials Congress
Number of pages1
StatePublished - Dec 1 2004
EventTransactions - 7th World Biomaterials Congress - Sydney, Australia
Duration: May 17 2004May 21 2004

Publication series

NameTransactions - 7th World Biomaterials Congress

Other

OtherTransactions - 7th World Biomaterials Congress
CountryAustralia
CitySydney
Period5/17/045/21/04

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ASJC Scopus subject areas

  • Engineering(all)

Cite this

Rehor, A., Tirelli, N., & Hubbell, J. A. (2004). Oxidative triggered release of doxorubicin from poly(sulfide) nanoparticles. In Transactions - 7th World Biomaterials Congress (Transactions - 7th World Biomaterials Congress).