Abstract
The incorporation and oxidative sensitive release of doxorubicin (DOX), a hydrophobic model drug widely used as a chemotherapeutic agent in cancer therapy, were demonstrated. Particles with mean diameters of 100nm were obtained by polymerizing poly(propylene sulfide) (PPS) in emulsion employing Pluronic F-127 as the only surfactant. Exposure of particles to H2O 2 led to a faster release, with 46% of loaded DOX released after 300h and simultaneous swelling and degradation of the particles. The absence of H2O2 release was assumed to occur by slow protonation of DOX at the Pluronic-PPS-hydrophilic-hydrophobic interface.
| Original language | English (US) |
|---|---|
| Title of host publication | Transactions - 7th World Biomaterials Congress |
| Number of pages | 1 |
| State | Published - Dec 1 2004 |
| Event | Transactions - 7th World Biomaterials Congress - Sydney, Australia Duration: May 17 2004 → May 21 2004 |
Publication series
| Name | Transactions - 7th World Biomaterials Congress |
|---|
Other
| Other | Transactions - 7th World Biomaterials Congress |
|---|---|
| Country | Australia |
| City | Sydney |
| Period | 5/17/04 → 5/21/04 |
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ASJC Scopus subject areas
- Engineering(all)
Cite this
Rehor, A., Tirelli, N., & Hubbell, J. A. (2004). Oxidative triggered release of doxorubicin from poly(sulfide) nanoparticles. In Transactions - 7th World Biomaterials Congress (Transactions - 7th World Biomaterials Congress).