Oxidative stress management in the hair follicle: Could targeting NRF2 counter age-related hair disorders and beyond?

Laura Jadkauskaite, Pierre A. Coulombe, Matthias Schäfer, Albena T. Dinkova-Kostova, Ralf Paus, Iain S. Haslam

Research output: Contribution to journalReview article

14 Scopus citations

Abstract

Widespread expression of the transcription factor, nuclear factor (erythroid-derived 2)-like 2 (NRF2), which maintains redox homeostasis, has recently been identified in the hair follicle (HF). Small molecule activators of NRF2 may therefore be useful in the management of HF pathologies associated with redox imbalance, ranging from HF greying and HF ageing via androgenetic alopecia and alopecia areata to chemotherapy-induced hair loss. Indeed, NRF2 activation has been shown to prevent peroxide-induced hair growth inhibition. Multiple parameters can increase the levels of reactive oxygen species in the HF, for example melanogenesis, depilation-induced trauma, neurogenic and autoimmune inflammation, toxic drugs, environmental stressors such as UV irradiation, genetic defects and aging-associated mitochondrial dysfunction. In this review, the potential mechanisms whereby NRF2 activation could prove beneficial in treatment of redox-associated HF disorders are therefore discussed.

Original languageEnglish (US)
Article number1700029
JournalBioEssays
Volume39
Issue number8
DOIs
StatePublished - Aug 1 2017
Externally publishedYes

Keywords

  • alopecia
  • chemotherapy and hair follicle
  • hair greying
  • inflammation
  • NRF2
  • oxidative stress

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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