Oxidative metabolic responses with recurrent seizures in rat cerebral cortex

Role of systemic factors

Norman R. Kreisman, Joseph C. Lamanna, Myron Rosenthal, Thomas Sick

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

Simultaneous focal measurements of cerebral oxygen tension and cytochrome a,a3 redox levels were made in rat cortex in order to obtain a direct and continuous assessment of oxidative metabolic changes during serial seizures. Initial seizures evoked by pentylenetetrazol were accompanied by transient increases in tissue pO2 and cytochrome a,a3 oxidation, confirming that oxygen provision is adequate to meet metabolic demand. After some point, subsequent seizures were accompanied by failure of pO2 to increase and failure of cytochrome a,a3 to oxidize, or by decreases in tissue pO2 and shifts in the redox level of cytochrome a,a3 toward reduction, signalling cortical oxygen insufficiency. Whereas early seizures were accompanied by increments in both cerebral blood volume and arterial blood pressure, one or both of these variables failed to increment during later seizures. This was particularly evident following the onset of spontaneously recurring seizures with short intervals between bursts of ECoG activity. These investigations emphasize the importance of systemic factors in determining the cerebral metabolic response to seizures and support the suggestion that neuronal damage in status epilepticus may be the result of derrangements of oxidative metabolism.

Original languageEnglish
Pages (from-to)175-188
Number of pages14
JournalBrain Research
Volume218
Issue number1-2
DOIs
StatePublished - Aug 10 1981

Fingerprint

Cerebral Cortex
Seizures
Electron Transport Complex IV
Oxygen
Oxidation-Reduction
Pentylenetetrazole
Status Epilepticus
Arterial Pressure

Keywords

  • cerebral vascular response
  • cytochrome oxidase
  • oxidative metabolism
  • oxygen tension
  • seizure
  • status epilepticus

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

Cite this

Oxidative metabolic responses with recurrent seizures in rat cerebral cortex : Role of systemic factors. / Kreisman, Norman R.; Lamanna, Joseph C.; Rosenthal, Myron; Sick, Thomas.

In: Brain Research, Vol. 218, No. 1-2, 10.08.1981, p. 175-188.

Research output: Contribution to journalArticle

Kreisman, Norman R. ; Lamanna, Joseph C. ; Rosenthal, Myron ; Sick, Thomas. / Oxidative metabolic responses with recurrent seizures in rat cerebral cortex : Role of systemic factors. In: Brain Research. 1981 ; Vol. 218, No. 1-2. pp. 175-188.
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