Oxidative metabolic responses during recurrent seizures are independent of convulsant, anesthetic, or species

N. R. Kreisman, M. Rosenthal, Thomas Sick, J. C. LaManna

Research output: Contribution to journalArticle

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Abstract

A transition from sufficient to insufficient cerebral oxygenation has been reported during recurrent seizures, but it was unknown whether this phenomenon was limited to particular species, anesthetics, or convulsant agents. Focal measurements were made of cortical Po2 and redox changes of cytochrome a,a3 in rats and cats anesthetized with sodium pentobarbital, nitrous oxide, or ketamine, or decerebrated. Seizures were induced with pentylenetetrazol, bicuculline, or electroconvulsive shock. Transition from oxygen sufficiency to insufficiency always occurred in association with inadequate vascular responses, regardless of experimental conditions. These results indicate that transition is a general characteristic of experimental status epilepticus.

Original languageEnglish
Pages (from-to)861-867
Number of pages7
JournalNeurology
Volume33
Issue number7
StatePublished - Jan 1 1983

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Convulsants
Anesthetics
Seizures
Electroshock
Pentylenetetrazole
Bicuculline
Status Epilepticus
Nitrous Oxide
Ketamine
Electron Transport Complex IV
Pentobarbital
Oxidation-Reduction
Blood Vessels
Cats
Oxygen

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Kreisman, N. R., Rosenthal, M., Sick, T., & LaManna, J. C. (1983). Oxidative metabolic responses during recurrent seizures are independent of convulsant, anesthetic, or species. Neurology, 33(7), 861-867.

Oxidative metabolic responses during recurrent seizures are independent of convulsant, anesthetic, or species. / Kreisman, N. R.; Rosenthal, M.; Sick, Thomas; LaManna, J. C.

In: Neurology, Vol. 33, No. 7, 01.01.1983, p. 861-867.

Research output: Contribution to journalArticle

Kreisman, NR, Rosenthal, M, Sick, T & LaManna, JC 1983, 'Oxidative metabolic responses during recurrent seizures are independent of convulsant, anesthetic, or species', Neurology, vol. 33, no. 7, pp. 861-867.
Kreisman, N. R. ; Rosenthal, M. ; Sick, Thomas ; LaManna, J. C. / Oxidative metabolic responses during recurrent seizures are independent of convulsant, anesthetic, or species. In: Neurology. 1983 ; Vol. 33, No. 7. pp. 861-867.
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