Oxidation-sensitive polymeric nanoparticles

Annemie Rehor, Jeffrey A. Hubbell, Nicola Tirelli

Research output: Contribution to journalArticle

119 Citations (Scopus)

Abstract

We have recently demonstrated the possible use of organic polysulfides for the design of oxidation-sensitive colloidal carriers in the form of polymeric vesicles, which are particularly suitable for the encapsulation of hydrosoluble drugs. In the present research we extend our efforts to carriers specifically suitable for hydrophobic molecules. Exploiting the living emulsion polymerization of episulfides, we have produced new cross-linked polysulfide nanoparticles. Here we demonstrate how this process allows the production of stable nanoparticles with a good control over their size and functionality. The nanoparticles showed negligible cytotoxicity on a fibroblast model; furthermore, they exhibited sensitivity to oxidative conditions, which first produce swelling and then solubilize the material.

Original languageEnglish
Pages (from-to)411-417
Number of pages7
JournalLangmuir
Volume21
Issue number1
DOIs
StatePublished - Jan 4 2005
Externally publishedYes

Fingerprint

polysulfides
Polysulfides
Nanoparticles
Oxidation
nanoparticles
oxidation
Living polymerization
Emulsion polymerization
fibroblasts
Fibroblasts
Cytotoxicity
Encapsulation
swelling
emulsions
Swelling
drugs
polymerization
Molecules
sensitivity
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry
  • Colloid and Surface Chemistry

Cite this

Rehor, A., Hubbell, J. A., & Tirelli, N. (2005). Oxidation-sensitive polymeric nanoparticles. Langmuir, 21(1), 411-417. https://doi.org/10.1021/la0478043

Oxidation-sensitive polymeric nanoparticles. / Rehor, Annemie; Hubbell, Jeffrey A.; Tirelli, Nicola.

In: Langmuir, Vol. 21, No. 1, 04.01.2005, p. 411-417.

Research output: Contribution to journalArticle

Rehor, A, Hubbell, JA & Tirelli, N 2005, 'Oxidation-sensitive polymeric nanoparticles', Langmuir, vol. 21, no. 1, pp. 411-417. https://doi.org/10.1021/la0478043
Rehor A, Hubbell JA, Tirelli N. Oxidation-sensitive polymeric nanoparticles. Langmuir. 2005 Jan 4;21(1):411-417. https://doi.org/10.1021/la0478043
Rehor, Annemie ; Hubbell, Jeffrey A. ; Tirelli, Nicola. / Oxidation-sensitive polymeric nanoparticles. In: Langmuir. 2005 ; Vol. 21, No. 1. pp. 411-417.
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