Oxidation-sensitive polymeric nanoparticles

Annemie Rehor, Jeffrey A. Hubbell, Nicola Tirelli

Research output: Contribution to journalArticle

121 Scopus citations

Abstract

We have recently demonstrated the possible use of organic polysulfides for the design of oxidation-sensitive colloidal carriers in the form of polymeric vesicles, which are particularly suitable for the encapsulation of hydrosoluble drugs. In the present research we extend our efforts to carriers specifically suitable for hydrophobic molecules. Exploiting the living emulsion polymerization of episulfides, we have produced new cross-linked polysulfide nanoparticles. Here we demonstrate how this process allows the production of stable nanoparticles with a good control over their size and functionality. The nanoparticles showed negligible cytotoxicity on a fibroblast model; furthermore, they exhibited sensitivity to oxidative conditions, which first produce swelling and then solubilize the material.

Original languageEnglish (US)
Pages (from-to)411-417
Number of pages7
JournalLangmuir
Volume21
Issue number1
DOIs
StatePublished - Jan 4 2005

ASJC Scopus subject areas

  • Materials Science(all)
  • Condensed Matter Physics
  • Surfaces and Interfaces
  • Spectroscopy
  • Electrochemistry

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    Rehor, A., Hubbell, J. A., & Tirelli, N. (2005). Oxidation-sensitive polymeric nanoparticles. Langmuir, 21(1), 411-417. https://doi.org/10.1021/la0478043