Oxidation-responsive polymeric vesicles

A. Napoli, N. Tirelli, J. A. Hubbell

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The role of a new class of oxidative-responsive polymeric vesicles that could be applied as nanocontainers in drug delivery, biosensing and biodetection was discussed. It was observed that the synthetic path was based on the anionic ring-opening polymerization of episulfides, initiated by a thiolate group. It was also found that the oxidation sensitivity of the vesicles were investigated by turbidimetry. Vesicle degradation was investigated when the oxidative environment was generated by the system glucose-oxidase (Gox)/glucose/O 2. A 1H nuclear magnetic resonance (NMR) spectroscopy of the polymersome suspensions was also employed before, during and after oxidation to characterize the nature of the observed morphological changes.

Original languageEnglish
Title of host publicationTransactions - 7th World Biomaterials Congress
StatePublished - Dec 1 2004
Externally publishedYes
EventTransactions - 7th World Biomaterials Congress - Sydney, Australia
Duration: May 17 2004May 21 2004

Other

OtherTransactions - 7th World Biomaterials Congress
CountryAustralia
CitySydney
Period5/17/045/21/04

Fingerprint

Oxidation
Glucose oxidase
Anionic polymerization
Ring opening polymerization
Drug delivery
Nuclear magnetic resonance spectroscopy
Glucose
Degradation

ASJC Scopus subject areas

  • Engineering(all)

Cite this

Napoli, A., Tirelli, N., & Hubbell, J. A. (2004). Oxidation-responsive polymeric vesicles. In Transactions - 7th World Biomaterials Congress

Oxidation-responsive polymeric vesicles. / Napoli, A.; Tirelli, N.; Hubbell, J. A.

Transactions - 7th World Biomaterials Congress. 2004.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Napoli, A, Tirelli, N & Hubbell, JA 2004, Oxidation-responsive polymeric vesicles. in Transactions - 7th World Biomaterials Congress. Transactions - 7th World Biomaterials Congress, Sydney, Australia, 5/17/04.
Napoli A, Tirelli N, Hubbell JA. Oxidation-responsive polymeric vesicles. In Transactions - 7th World Biomaterials Congress. 2004
Napoli, A. ; Tirelli, N. ; Hubbell, J. A. / Oxidation-responsive polymeric vesicles. Transactions - 7th World Biomaterials Congress. 2004.
@inproceedings{c794a7f83a7d466695c5cb75b77efbf2,
title = "Oxidation-responsive polymeric vesicles",
abstract = "The role of a new class of oxidative-responsive polymeric vesicles that could be applied as nanocontainers in drug delivery, biosensing and biodetection was discussed. It was observed that the synthetic path was based on the anionic ring-opening polymerization of episulfides, initiated by a thiolate group. It was also found that the oxidation sensitivity of the vesicles were investigated by turbidimetry. Vesicle degradation was investigated when the oxidative environment was generated by the system glucose-oxidase (Gox)/glucose/O 2. A 1H nuclear magnetic resonance (NMR) spectroscopy of the polymersome suspensions was also employed before, during and after oxidation to characterize the nature of the observed morphological changes.",
author = "A. Napoli and N. Tirelli and Hubbell, {J. A.}",
year = "2004",
month = "12",
day = "1",
language = "English",
isbn = "1877040193",
booktitle = "Transactions - 7th World Biomaterials Congress",

}

TY - GEN

T1 - Oxidation-responsive polymeric vesicles

AU - Napoli, A.

AU - Tirelli, N.

AU - Hubbell, J. A.

PY - 2004/12/1

Y1 - 2004/12/1

N2 - The role of a new class of oxidative-responsive polymeric vesicles that could be applied as nanocontainers in drug delivery, biosensing and biodetection was discussed. It was observed that the synthetic path was based on the anionic ring-opening polymerization of episulfides, initiated by a thiolate group. It was also found that the oxidation sensitivity of the vesicles were investigated by turbidimetry. Vesicle degradation was investigated when the oxidative environment was generated by the system glucose-oxidase (Gox)/glucose/O 2. A 1H nuclear magnetic resonance (NMR) spectroscopy of the polymersome suspensions was also employed before, during and after oxidation to characterize the nature of the observed morphological changes.

AB - The role of a new class of oxidative-responsive polymeric vesicles that could be applied as nanocontainers in drug delivery, biosensing and biodetection was discussed. It was observed that the synthetic path was based on the anionic ring-opening polymerization of episulfides, initiated by a thiolate group. It was also found that the oxidation sensitivity of the vesicles were investigated by turbidimetry. Vesicle degradation was investigated when the oxidative environment was generated by the system glucose-oxidase (Gox)/glucose/O 2. A 1H nuclear magnetic resonance (NMR) spectroscopy of the polymersome suspensions was also employed before, during and after oxidation to characterize the nature of the observed morphological changes.

UR - http://www.scopus.com/inward/record.url?scp=13844272298&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=13844272298&partnerID=8YFLogxK

M3 - Conference contribution

SN - 1877040193

SN - 9781877040191

BT - Transactions - 7th World Biomaterials Congress

ER -