Oxidation-responsive polymeric vesicles

A. Napoli, N. Tirelli, J. A. Hubbell

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The role of a new class of oxidative-responsive polymeric vesicles that could be applied as nanocontainers in drug delivery, biosensing and biodetection was discussed. It was observed that the synthetic path was based on the anionic ring-opening polymerization of episulfides, initiated by a thiolate group. It was also found that the oxidation sensitivity of the vesicles were investigated by turbidimetry. Vesicle degradation was investigated when the oxidative environment was generated by the system glucose-oxidase (Gox)/glucose/O 2. A 1H nuclear magnetic resonance (NMR) spectroscopy of the polymersome suspensions was also employed before, during and after oxidation to characterize the nature of the observed morphological changes.

Original languageEnglish (US)
Title of host publicationTransactions - 7th World Biomaterials Congress
Number of pages1
StatePublished - Dec 1 2004
EventTransactions - 7th World Biomaterials Congress - Sydney, Australia
Duration: May 17 2004May 21 2004

Publication series

NameTransactions - 7th World Biomaterials Congress

Other

OtherTransactions - 7th World Biomaterials Congress
CountryAustralia
CitySydney
Period5/17/045/21/04

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ASJC Scopus subject areas

  • Engineering(all)

Cite this

Napoli, A., Tirelli, N., & Hubbell, J. A. (2004). Oxidation-responsive polymeric vesicles. In Transactions - 7th World Biomaterials Congress (Transactions - 7th World Biomaterials Congress).