Ovulation induction. Ovarian response to human gonadotropins and synthetic gonadotropin releasing hormone

J. Zanartu, A. Dabancens, R. Rodriguez-Bravo, F. Barsby, Andrew V Schally

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Human ovarian responses to FSH and LH releasing hormone (FSH/LH RH) were observed at laparotomy and studied by histologic and histochemical examination of ovarian biopsy specimens. The responses were compared to those induced by human menopausal gonadotropin (HMG) and human chorionic gonadotropin (HCG) singly and together. The subjects were healthy, fertile, young women rendered anovulatory by injections of depomedroxyprogesterone acetate (DMPA) or depochlormadinone acetate (CA). Supplementary studies included measurement of urinary pregnanediol, examination of the cervix and vagina for estrogenic and progestational responses, and endometrial biopsy. Both HMG and HCG induced follicular growth and proliferation of granulosa and theca cells, but neither, when given alone, induced ovulation or corpus luteum formation. When given in conjunction they induced single or multiple ovulations and corpora lutea in 11 of 18 women treated. FSH/LH RH consistently stimulated follicular development and induced ovulation in 2 of 16 women treated. Preovulatory mature follicles were found in 3 more. FSH/LH RH may prove to be useful in the treatment of some cases of anovulatory sterility of hypothalamic origin.

Original languageEnglish
Pages (from-to)443-450
Number of pages8
JournalObstetrics and Gynecology
Volume45
Issue number4
StatePublished - Dec 1 1975
Externally publishedYes

Fingerprint

Ovulation Induction
Ovulation
Gonadotropins
Gonadotropin-Releasing Hormone
Menotropins
Corpus Luteum
Chorionic Gonadotropin
Pregnanediol
Theca Cells
Biopsy
Granulosa Cells
Vagina
Cervix Uteri
Laparotomy
Infertility
Healthy Volunteers
Acetates
Injections
Growth
Therapeutics

ASJC Scopus subject areas

  • Obstetrics and Gynecology

Cite this

Ovulation induction. Ovarian response to human gonadotropins and synthetic gonadotropin releasing hormone. / Zanartu, J.; Dabancens, A.; Rodriguez-Bravo, R.; Barsby, F.; Schally, Andrew V.

In: Obstetrics and Gynecology, Vol. 45, No. 4, 01.12.1975, p. 443-450.

Research output: Contribution to journalArticle

Zanartu, J, Dabancens, A, Rodriguez-Bravo, R, Barsby, F & Schally, AV 1975, 'Ovulation induction. Ovarian response to human gonadotropins and synthetic gonadotropin releasing hormone', Obstetrics and Gynecology, vol. 45, no. 4, pp. 443-450.
Zanartu, J. ; Dabancens, A. ; Rodriguez-Bravo, R. ; Barsby, F. ; Schally, Andrew V. / Ovulation induction. Ovarian response to human gonadotropins and synthetic gonadotropin releasing hormone. In: Obstetrics and Gynecology. 1975 ; Vol. 45, No. 4. pp. 443-450.
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