Ovulation confirmed by pregnancy after infusion of porcine LH-RH

Abba J. Kastin, Arturo Zarate, A. Rees Midgley, Elias S. Canales, Andrew V. Schally

Research output: Contribution to journalArticlepeer-review

36 Scopus citations

Abstract

Luteinizing hormone-releasing hormone (LH-RH), purified from porcine hypothalami, was infused iv for 24 hours into a woman with secondary amenorrhea who was pretreated with human menopausal gonadotropin (HMG-Pergonal). Supplemental LH-RH was injected iv rapidly at 8 and 24 hours during the infusion. Ovulation, indicated by the marked rise in urinary pregnanediol levels, was confirmed by pregnancy. During a control cycle in which HMG but not LH-RH was administered, no rise in urinary pregnanediol values occurred. It is suggested that LH-RH may be useful in the treatment of some cases of infertility.

Original languageEnglish (US)
Pages (from-to)980-982
Number of pages3
JournalJournal of Clinical Endocrinology and Metabolism
Volume33
Issue number6
DOIs
StatePublished - Jan 1 1971
Externally publishedYes

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Endocrinology
  • Clinical Biochemistry
  • Biochemistry, medical

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