Abstract
Objective: To evaluate the effect of obesity on the outcome of testicular sperm extraction (TESE) and assisted reproductive technology. Design: Clinical retrospective study. Setting: Center for reproductive medicine at a tertiary-care university hospital. Patient(s): Nine hundred seventy patients with nonobstructive azoospermia. Intervention(s): Microdissection TESE followed by intracytoplasmic sperm injection (ICSI). Main Outcome Measure(s): Sperm retrieval rate and clinical pregnancy rate. Result(s): Testicular sperm were successfully retrieved in 55% of men overall. Of those with sperm found, clinical pregnancy rate was 51% and live birth rate 40%. Sperm retrieval rates were similar in men with body mass index (BMI) 2, 25-30 kg/m2, and >30 kg/m2 (59%, 57%, and 54%, respectively). Mean BMI of men who contributed to pregnancy (27.3 ± 4.9 kg/m 2) was lower than for men whose sperm did not contribute to a pregnancy (28.2 ± 5.4 kg/m2). No man with BMI >43 kg/m 2 (n = 11) contributed to a successful pregnancy, even though sperm were found in men with BMI up to 57 kg/m2. On multivariable logistic regression analysis, male BMI was the only predictor of successful pregnancy among the variables analyzed, including male age, female age, and female BMI. Conclusion(s): Overweight men have lower clinical pregnancy rate after microdissection TESE and ICSI compared with men with normal BMI. Men with BMI >43 kg/m2 did not contribute to any pregnancies, despite successful sperm retrieval.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 372-376 |
| Number of pages | 5 |
| Journal | Fertility and Sterility |
| Volume | 99 |
| Issue number | 2 |
| DOIs | |
| State | Published - Feb 2013 |
| Externally published | Yes |
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Keywords
- biopsy
- BMI
- obesity
- retrieval
- Testis
ASJC Scopus subject areas
- Obstetrics and Gynecology
- Reproductive Medicine
Cite this
Overweight men with nonobstructive azoospermia have worse pregnancy outcomes after microdissection testicular sperm extraction. / Ramasamy, Ranjith; Bryson, Campbell; Reifsnyder, Jennifer E.; Neri, Queenie; Palermo, Gianpiero D.; Schlegel, Peter N.
In: Fertility and Sterility, Vol. 99, No. 2, 02.2013, p. 372-376.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Overweight men with nonobstructive azoospermia have worse pregnancy outcomes after microdissection testicular sperm extraction
AU - Ramasamy, Ranjith
AU - Bryson, Campbell
AU - Reifsnyder, Jennifer E.
AU - Neri, Queenie
AU - Palermo, Gianpiero D.
AU - Schlegel, Peter N.
PY - 2013/2
Y1 - 2013/2
N2 - Objective: To evaluate the effect of obesity on the outcome of testicular sperm extraction (TESE) and assisted reproductive technology. Design: Clinical retrospective study. Setting: Center for reproductive medicine at a tertiary-care university hospital. Patient(s): Nine hundred seventy patients with nonobstructive azoospermia. Intervention(s): Microdissection TESE followed by intracytoplasmic sperm injection (ICSI). Main Outcome Measure(s): Sperm retrieval rate and clinical pregnancy rate. Result(s): Testicular sperm were successfully retrieved in 55% of men overall. Of those with sperm found, clinical pregnancy rate was 51% and live birth rate 40%. Sperm retrieval rates were similar in men with body mass index (BMI) 2, 25-30 kg/m2, and >30 kg/m2 (59%, 57%, and 54%, respectively). Mean BMI of men who contributed to pregnancy (27.3 ± 4.9 kg/m 2) was lower than for men whose sperm did not contribute to a pregnancy (28.2 ± 5.4 kg/m2). No man with BMI >43 kg/m 2 (n = 11) contributed to a successful pregnancy, even though sperm were found in men with BMI up to 57 kg/m2. On multivariable logistic regression analysis, male BMI was the only predictor of successful pregnancy among the variables analyzed, including male age, female age, and female BMI. Conclusion(s): Overweight men have lower clinical pregnancy rate after microdissection TESE and ICSI compared with men with normal BMI. Men with BMI >43 kg/m2 did not contribute to any pregnancies, despite successful sperm retrieval.
AB - Objective: To evaluate the effect of obesity on the outcome of testicular sperm extraction (TESE) and assisted reproductive technology. Design: Clinical retrospective study. Setting: Center for reproductive medicine at a tertiary-care university hospital. Patient(s): Nine hundred seventy patients with nonobstructive azoospermia. Intervention(s): Microdissection TESE followed by intracytoplasmic sperm injection (ICSI). Main Outcome Measure(s): Sperm retrieval rate and clinical pregnancy rate. Result(s): Testicular sperm were successfully retrieved in 55% of men overall. Of those with sperm found, clinical pregnancy rate was 51% and live birth rate 40%. Sperm retrieval rates were similar in men with body mass index (BMI) 2, 25-30 kg/m2, and >30 kg/m2 (59%, 57%, and 54%, respectively). Mean BMI of men who contributed to pregnancy (27.3 ± 4.9 kg/m 2) was lower than for men whose sperm did not contribute to a pregnancy (28.2 ± 5.4 kg/m2). No man with BMI >43 kg/m 2 (n = 11) contributed to a successful pregnancy, even though sperm were found in men with BMI up to 57 kg/m2. On multivariable logistic regression analysis, male BMI was the only predictor of successful pregnancy among the variables analyzed, including male age, female age, and female BMI. Conclusion(s): Overweight men have lower clinical pregnancy rate after microdissection TESE and ICSI compared with men with normal BMI. Men with BMI >43 kg/m2 did not contribute to any pregnancies, despite successful sperm retrieval.
KW - biopsy
KW - BMI
KW - obesity
KW - retrieval
KW - Testis
UR - http://www.scopus.com/inward/record.url?scp=84873294729&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84873294729&partnerID=8YFLogxK
U2 - 10.1016/j.fertnstert.2012.10.025
DO - 10.1016/j.fertnstert.2012.10.025
M3 - Article
C2 - 23122830
AN - SCOPUS:84873294729
VL - 99
SP - 372
EP - 376
JO - Fertility and Sterility
JF - Fertility and Sterility
SN - 0015-0282
IS - 2
ER -