Overweight men with nonobstructive azoospermia have worse pregnancy outcomes after microdissection testicular sperm extraction

Ranjith Ramasamy, Campbell Bryson, Jennifer E. Reifsnyder, Queenie Neri, Gianpiero D. Palermo, Peter N. Schlegel

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Objective: To evaluate the effect of obesity on the outcome of testicular sperm extraction (TESE) and assisted reproductive technology. Design: Clinical retrospective study. Setting: Center for reproductive medicine at a tertiary-care university hospital. Patient(s): Nine hundred seventy patients with nonobstructive azoospermia. Intervention(s): Microdissection TESE followed by intracytoplasmic sperm injection (ICSI). Main Outcome Measure(s): Sperm retrieval rate and clinical pregnancy rate. Result(s): Testicular sperm were successfully retrieved in 55% of men overall. Of those with sperm found, clinical pregnancy rate was 51% and live birth rate 40%. Sperm retrieval rates were similar in men with body mass index (BMI) 2, 25-30 kg/m2, and >30 kg/m2 (59%, 57%, and 54%, respectively). Mean BMI of men who contributed to pregnancy (27.3 ± 4.9 kg/m 2) was lower than for men whose sperm did not contribute to a pregnancy (28.2 ± 5.4 kg/m2). No man with BMI >43 kg/m 2 (n = 11) contributed to a successful pregnancy, even though sperm were found in men with BMI up to 57 kg/m2. On multivariable logistic regression analysis, male BMI was the only predictor of successful pregnancy among the variables analyzed, including male age, female age, and female BMI. Conclusion(s): Overweight men have lower clinical pregnancy rate after microdissection TESE and ICSI compared with men with normal BMI. Men with BMI >43 kg/m2 did not contribute to any pregnancies, despite successful sperm retrieval.

Original languageEnglish (US)
Pages (from-to)372-376
Number of pages5
JournalFertility and Sterility
Volume99
Issue number2
DOIs
StatePublished - Feb 2013
Externally publishedYes

Fingerprint

Microdissection
Pregnancy Outcome
Spermatozoa
Body Mass Index
Sperm Retrieval
Pregnancy Rate
Pregnancy
Intracytoplasmic Sperm Injections
Reproductive Medicine
Nonobstructive Azoospermia
Assisted Reproductive Techniques
Birth Rate
Live Birth
Tertiary Healthcare
Retrospective Studies
Obesity
Logistic Models
Regression Analysis
Outcome Assessment (Health Care)

Keywords

  • biopsy
  • BMI
  • obesity
  • retrieval
  • Testis

ASJC Scopus subject areas

  • Obstetrics and Gynecology
  • Reproductive Medicine

Cite this

Overweight men with nonobstructive azoospermia have worse pregnancy outcomes after microdissection testicular sperm extraction. / Ramasamy, Ranjith; Bryson, Campbell; Reifsnyder, Jennifer E.; Neri, Queenie; Palermo, Gianpiero D.; Schlegel, Peter N.

In: Fertility and Sterility, Vol. 99, No. 2, 02.2013, p. 372-376.

Research output: Contribution to journalArticle

Ramasamy, Ranjith ; Bryson, Campbell ; Reifsnyder, Jennifer E. ; Neri, Queenie ; Palermo, Gianpiero D. ; Schlegel, Peter N. / Overweight men with nonobstructive azoospermia have worse pregnancy outcomes after microdissection testicular sperm extraction. In: Fertility and Sterility. 2013 ; Vol. 99, No. 2. pp. 372-376.
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