Overview of HIV

Nancy Klimas, Anne O Brien Koneru, Mary Ann Fletcher

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

This article provides an overview and reviews the HIV pandemic, the basic biology and immunology of the virus (e.g., genetic diversity of HIV and the viral life cycle), the phases of disease progression, modes of HIV transmission, HIV testing, immune response to the infection, and current therapeutic strategies. HIV is occurring in epidemic proportions, especially in Sub-Saharan Africa. In the US, men who have sex with men account for over half of AIDS diagnoses; racial and ethnic minorities are disproportionally affected. Factors influencing the progression and severity of HIV infection include type of immune response, coinfection (e.g., another sexually transmitted infection, including hepatitis B or C), age and behavioral and psychosocial factors. Antiretroviral therapies can achieve reduction in blood levels of the HIV virus below the limits of detection by current technology. However, effective treatment requires adherence to therapy. Patient failure to adhere to treatment regimens results in detectible circulating virus and in HIV disease progression, and is the primary cause of drug resistance. In addition to research on the immunology and virology of the disease, other studies focus on behavioral and psychosocial factors that may affect medication adherence and risk behaviors.

Original languageEnglish
Pages (from-to)523-530
Number of pages8
JournalPsychosomatic Medicine
Volume70
Issue number5
DOIs
StatePublished - Jun 1 2008
Externally publishedYes

Fingerprint

HIV
Viruses
Allergy and Immunology
Disease Progression
Psychology
Therapeutics
Virology
Medication Adherence
Africa South of the Sahara
Age Factors
Pandemics
Hepatitis C
Sexually Transmitted Diseases
Risk-Taking
Life Cycle Stages
Hepatitis B
Coinfection
Drug Resistance
HIV Infections
Limit of Detection

Keywords

  • Disease progression
  • HIV/AIDS
  • Immune response
  • Treatment

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Applied Psychology
  • Psychology(all)

Cite this

Klimas, N., Koneru, A. O. B., & Fletcher, M. A. (2008). Overview of HIV. Psychosomatic Medicine, 70(5), 523-530. https://doi.org/10.1097/PSY.0b013e31817ae69f

Overview of HIV. / Klimas, Nancy; Koneru, Anne O Brien; Fletcher, Mary Ann.

In: Psychosomatic Medicine, Vol. 70, No. 5, 01.06.2008, p. 523-530.

Research output: Contribution to journalArticle

Klimas, N, Koneru, AOB & Fletcher, MA 2008, 'Overview of HIV', Psychosomatic Medicine, vol. 70, no. 5, pp. 523-530. https://doi.org/10.1097/PSY.0b013e31817ae69f
Klimas N, Koneru AOB, Fletcher MA. Overview of HIV. Psychosomatic Medicine. 2008 Jun 1;70(5):523-530. https://doi.org/10.1097/PSY.0b013e31817ae69f
Klimas, Nancy ; Koneru, Anne O Brien ; Fletcher, Mary Ann. / Overview of HIV. In: Psychosomatic Medicine. 2008 ; Vol. 70, No. 5. pp. 523-530.
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