Vaccine immunotherapy for pediatric CNS malignancy is a new and developing field, primarily aimed at glial tumors. Vaccines typically must be found safe and effective in adults before being tested in children. There are three major types of tumor vaccines: dendritic cell (DC), peptide, and vector-based. All vaccines directed at pediatric CNS tumors currently remain in pilot or Phase I trials, evaluating feasibility and safety, respectively. Immune response and improved clinical outcomes have been documented as secondary measures in some cases. In this chapter, we will present a thorough review of vaccine therapy for pediatric CNS tumors.
|Original language||English (US)|
|Title of host publication||Handbook of Brain Tumor Chemotherapy, Molecular Therapeutics, and Immunotherapy|
|Subtitle of host publication||Second Edition|
|Number of pages||5|
|State||Published - Apr 24 2018|
- Brain tumor
ASJC Scopus subject areas