Overview of CNS Vaccines-Pediatrics

Joanna E. Gernsback, John Paul G. Kolcun, Sheikh C. Ali, Ricardo J Komotar

Research output: Chapter in Book/Report/Conference proceedingChapter


Vaccine immunotherapy for pediatric CNS malignancy is a new and developing field, primarily aimed at glial tumors. Vaccines typically must be found safe and effective in adults before being tested in children. There are three major types of tumor vaccines: dendritic cell (DC), peptide, and vector-based. All vaccines directed at pediatric CNS tumors currently remain in pilot or Phase I trials, evaluating feasibility and safety, respectively. Immune response and improved clinical outcomes have been documented as secondary measures in some cases. In this chapter, we will present a thorough review of vaccine therapy for pediatric CNS tumors.

Original languageEnglish (US)
Title of host publicationHandbook of Brain Tumor Chemotherapy, Molecular Therapeutics, and Immunotherapy
Subtitle of host publicationSecond Edition
PublisherElsevier Inc.
Number of pages5
ISBN (Print)9780128121009
StatePublished - Apr 24 2018
Externally publishedYes


  • Brain tumor
  • Glioma
  • Immunotherapy
  • Pediatric
  • Vaccine

ASJC Scopus subject areas

  • Medicine(all)
  • Neuroscience(all)


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