Abstract
Ceramide, which forms through the activation of sphingomyelinases (SMases), is as a bioactive lipid that mediates cell growth, differentiation, stress responses, and programmed cell death (apoptosis). Molecular and biochemical examinations to determine the role of these enzymes in ceramide-mediated cell signaling is possible with the recent availability of the cloned acid SMase (A-SMase) and neutral SMase (N-SMase). Here we review the recent experimental data and discuss its relevance for understanding the biochemical and molecular properties, regulation, mechanisms and roles of A-SMase and N-SMase.
| Original language | English (US) |
|---|---|
| Title of host publication | Sphingolipid Biology |
| Publisher | Springer Japan |
| Pages | 167-181 |
| Number of pages | 15 |
| ISBN (Print) | 4431341986, 9784431341987 |
| DOIs | |
| State | Published - 2006 |
| Externally published | Yes |
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Keywords
- apoptosis
- ceramide
- FAN (factor associated with N-SMase activation)
- Niemann Pick disease (NPD)
- sphingomyelinase
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
Cite this
Overview of acid and neutral sphingomyelinases in cell signaling. / Zeidan, Youssef; Marchesini, Norma; Hannun, Yusuf A.
Sphingolipid Biology. Springer Japan, 2006. p. 167-181.Research output: Chapter in Book/Report/Conference proceeding › Chapter
}
TY - CHAP
T1 - Overview of acid and neutral sphingomyelinases in cell signaling
AU - Zeidan, Youssef
AU - Marchesini, Norma
AU - Hannun, Yusuf A.
PY - 2006
Y1 - 2006
N2 - Ceramide, which forms through the activation of sphingomyelinases (SMases), is as a bioactive lipid that mediates cell growth, differentiation, stress responses, and programmed cell death (apoptosis). Molecular and biochemical examinations to determine the role of these enzymes in ceramide-mediated cell signaling is possible with the recent availability of the cloned acid SMase (A-SMase) and neutral SMase (N-SMase). Here we review the recent experimental data and discuss its relevance for understanding the biochemical and molecular properties, regulation, mechanisms and roles of A-SMase and N-SMase.
AB - Ceramide, which forms through the activation of sphingomyelinases (SMases), is as a bioactive lipid that mediates cell growth, differentiation, stress responses, and programmed cell death (apoptosis). Molecular and biochemical examinations to determine the role of these enzymes in ceramide-mediated cell signaling is possible with the recent availability of the cloned acid SMase (A-SMase) and neutral SMase (N-SMase). Here we review the recent experimental data and discuss its relevance for understanding the biochemical and molecular properties, regulation, mechanisms and roles of A-SMase and N-SMase.
KW - apoptosis
KW - ceramide
KW - FAN (factor associated with N-SMase activation)
KW - Niemann Pick disease (NPD)
KW - sphingomyelinase
UR - http://www.scopus.com/inward/record.url?scp=84900702442&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84900702442&partnerID=8YFLogxK
U2 - 10.1007/4-431-34200-1_12
DO - 10.1007/4-431-34200-1_12
M3 - Chapter
AN - SCOPUS:84900702442
SN - 4431341986
SN - 9784431341987
SP - 167
EP - 181
BT - Sphingolipid Biology
PB - Springer Japan
ER -