Overview of acid and neutral sphingomyelinases in cell signaling

Youssef Zeidan; Norma Marchesini; Yusuf A. Hannun

doi:10.1007/4-431-34200-1_12

Overview of acid and neutral sphingomyelinases in cell signaling

Youssef Zeidan, Norma Marchesini, Yusuf A. Hannun

Radiation Oncology

Research output: Chapter in Book/Report/Conference proceeding › Chapter

1 Scopus citations

Abstract

Ceramide, which forms through the activation of sphingomyelinases (SMases), is as a bioactive lipid that mediates cell growth, differentiation, stress responses, and programmed cell death (apoptosis). Molecular and biochemical examinations to determine the role of these enzymes in ceramide-mediated cell signaling is possible with the recent availability of the cloned acid SMase (A-SMase) and neutral SMase (N-SMase). Here we review the recent experimental data and discuss its relevance for understanding the biochemical and molecular properties, regulation, mechanisms and roles of A-SMase and N-SMase.

Original language	English (US)
Title of host publication	Sphingolipid Biology
Publisher	Springer Japan
Pages	167-181
Number of pages	15
ISBN (Print)	4431341986, 9784431341987
DOIs	https://doi.org/10.1007/4-431-34200-1_12
State	Published - Dec 1 2006

Keywords

FAN (factor associated with N-SMase activation)
Niemann Pick disease (NPD)
apoptosis
ceramide
sphingomyelinase

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

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10.1007/4-431-34200-1_12

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abstract = "Ceramide, which forms through the activation of sphingomyelinases (SMases), is as a bioactive lipid that mediates cell growth, differentiation, stress responses, and programmed cell death (apoptosis). Molecular and biochemical examinations to determine the role of these enzymes in ceramide-mediated cell signaling is possible with the recent availability of the cloned acid SMase (A-SMase) and neutral SMase (N-SMase). Here we review the recent experimental data and discuss its relevance for understanding the biochemical and molecular properties, regulation, mechanisms and roles of A-SMase and N-SMase.",

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AU - Marchesini, Norma

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N2 - Ceramide, which forms through the activation of sphingomyelinases (SMases), is as a bioactive lipid that mediates cell growth, differentiation, stress responses, and programmed cell death (apoptosis). Molecular and biochemical examinations to determine the role of these enzymes in ceramide-mediated cell signaling is possible with the recent availability of the cloned acid SMase (A-SMase) and neutral SMase (N-SMase). Here we review the recent experimental data and discuss its relevance for understanding the biochemical and molecular properties, regulation, mechanisms and roles of A-SMase and N-SMase.

AB - Ceramide, which forms through the activation of sphingomyelinases (SMases), is as a bioactive lipid that mediates cell growth, differentiation, stress responses, and programmed cell death (apoptosis). Molecular and biochemical examinations to determine the role of these enzymes in ceramide-mediated cell signaling is possible with the recent availability of the cloned acid SMase (A-SMase) and neutral SMase (N-SMase). Here we review the recent experimental data and discuss its relevance for understanding the biochemical and molecular properties, regulation, mechanisms and roles of A-SMase and N-SMase.

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KW - Niemann Pick disease (NPD)

KW - apoptosis

KW - ceramide

KW - sphingomyelinase

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Overview of acid and neutral sphingomyelinases in cell signaling

Abstract

Keywords

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