Overview of acid and neutral sphingomyelinases in cell signaling

Youssef Zeidan, Norma Marchesini, Yusuf A. Hannun

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations


Ceramide, which forms through the activation of sphingomyelinases (SMases), is as a bioactive lipid that mediates cell growth, differentiation, stress responses, and programmed cell death (apoptosis). Molecular and biochemical examinations to determine the role of these enzymes in ceramide-mediated cell signaling is possible with the recent availability of the cloned acid SMase (A-SMase) and neutral SMase (N-SMase). Here we review the recent experimental data and discuss its relevance for understanding the biochemical and molecular properties, regulation, mechanisms and roles of A-SMase and N-SMase.

Original languageEnglish (US)
Title of host publicationSphingolipid Biology
PublisherSpringer Japan
Number of pages15
ISBN (Print)4431341986, 9784431341987
StatePublished - Dec 1 2006


  • FAN (factor associated with N-SMase activation)
  • Niemann Pick disease (NPD)
  • apoptosis
  • ceramide
  • sphingomyelinase

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)


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