Abstract
Overlap syndromes are inflammatory rheumatic conditions in which patients have clinical manifestations suggestive of multiple distinct immune diseases. The diseases most commonly involved in overlap syndromes include rheumatoid arthritis, lupus, scleroderma, and myositis. The most well-characterized overlap syndrome, mixed connective tissue disease (MCTD), is defined by anti-RNP autoimmunity along with features of at least two of these four conditions, and very often includes sufficient lupus manifestations to fulfill the SLICC lupus classification criteria. Overlap syndromes are generally less common than the conditions they encompass; the prevalence of MCTD, for example, is approximately one-twentieth that of SLE. Some autoantigen systems are particularly linked with overlap syndromes, such as RNP in MCTD. Overlap syndromes provide unique opportunities to understand links between autoimmunity and end organ immune targeting. While insights can be extrapolated from studies of disease processes present in overlap, few treatment trials have focused specifically on overlap syndromes themselves.
| Original language | English (US) |
|---|---|
| Title of host publication | Systemic Lupus Erythematosus: Basic, Applied and Clinical Aspects |
| Publisher | Elsevier Inc. |
| Pages | 425-430 |
| Number of pages | 6 |
| ISBN (Print) | 9780128020098, 9780128019177 |
| DOIs | |
| State | Published - 2016 |
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Keywords
- Mixed connective tissue disease
- Myositis
- Rheumatoid arthritis
- RNP
- Scleroderma
ASJC Scopus subject areas
- Medicine(all)
- Immunology and Microbiology(all)
Cite this
Overlap Syndromes. / Greidinger, Eric L.
Systemic Lupus Erythematosus: Basic, Applied and Clinical Aspects. Elsevier Inc., 2016. p. 425-430.Research output: Chapter in Book/Report/Conference proceeding › Chapter
}
TY - CHAP
T1 - Overlap Syndromes
AU - Greidinger, Eric L
PY - 2016
Y1 - 2016
N2 - Overlap syndromes are inflammatory rheumatic conditions in which patients have clinical manifestations suggestive of multiple distinct immune diseases. The diseases most commonly involved in overlap syndromes include rheumatoid arthritis, lupus, scleroderma, and myositis. The most well-characterized overlap syndrome, mixed connective tissue disease (MCTD), is defined by anti-RNP autoimmunity along with features of at least two of these four conditions, and very often includes sufficient lupus manifestations to fulfill the SLICC lupus classification criteria. Overlap syndromes are generally less common than the conditions they encompass; the prevalence of MCTD, for example, is approximately one-twentieth that of SLE. Some autoantigen systems are particularly linked with overlap syndromes, such as RNP in MCTD. Overlap syndromes provide unique opportunities to understand links between autoimmunity and end organ immune targeting. While insights can be extrapolated from studies of disease processes present in overlap, few treatment trials have focused specifically on overlap syndromes themselves.
AB - Overlap syndromes are inflammatory rheumatic conditions in which patients have clinical manifestations suggestive of multiple distinct immune diseases. The diseases most commonly involved in overlap syndromes include rheumatoid arthritis, lupus, scleroderma, and myositis. The most well-characterized overlap syndrome, mixed connective tissue disease (MCTD), is defined by anti-RNP autoimmunity along with features of at least two of these four conditions, and very often includes sufficient lupus manifestations to fulfill the SLICC lupus classification criteria. Overlap syndromes are generally less common than the conditions they encompass; the prevalence of MCTD, for example, is approximately one-twentieth that of SLE. Some autoantigen systems are particularly linked with overlap syndromes, such as RNP in MCTD. Overlap syndromes provide unique opportunities to understand links between autoimmunity and end organ immune targeting. While insights can be extrapolated from studies of disease processes present in overlap, few treatment trials have focused specifically on overlap syndromes themselves.
KW - Mixed connective tissue disease
KW - Myositis
KW - Rheumatoid arthritis
KW - RNP
KW - Scleroderma
UR - http://www.scopus.com/inward/record.url?scp=84966929736&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84966929736&partnerID=8YFLogxK
U2 - 10.1016/B978-0-12-801917-7.00048-6
DO - 10.1016/B978-0-12-801917-7.00048-6
M3 - Chapter
AN - SCOPUS:84966929736
SN - 9780128020098
SN - 9780128019177
SP - 425
EP - 430
BT - Systemic Lupus Erythematosus: Basic, Applied and Clinical Aspects
PB - Elsevier Inc.
ER -