Overexpressed differentiation antigens as targets of graft-versus-leukemia reactions

Jeffrey J. Molldrem, Krishna Komanduri, Eric Wieder

Research output: Contribution to journalReview article

44 Scopus citations

Abstract

The graft-versus-leukemia (GVL) effect associated with allogeneic blood and marrow transplantation has largely been a clinically described phenomenon until recently. We are beginning to understand the cellular and molecular nature of GVL, and in this review the authors highlight the potential for self-antigen-specific T lymphocytes to contribute to GVL. The authors focus on myeloid tissue-restricted proteins as GVL target antigens in CML and AML, and in particular on proteinase 3 and other azurophil granule proteins as targets for both autologous and allogeneic T-cell responses. Finally, the authors discuss myeloid self-antigen-directed alloreactivity in the context of our evolving understanding of the critical molecular determinants of allogeneic T-cell recognition. By altering T-cell receptor affinity, peptide specificity can be maintained and the potency of immunity can be enhanced in the MHC-mismatched setting.

Original languageEnglish (US)
Pages (from-to)503-508
Number of pages6
JournalCurrent Opinion in Hematology
Volume9
Issue number6
DOIs
StatePublished - Nov 1 2002
Externally publishedYes

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ASJC Scopus subject areas

  • Hematology

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