Ovarian stimulation for in-vitro fertilization combining administration of gonadotrophins and blockade of the pituitary with D-Trp6-LHRH microcapsules: Pilot studies with two protocols

J. R. Zorn, M. Barata, C. Brami, S. Epelboin, C. Nathan, G. Papageorgiou, P. Quantin, F. Rolet, M. Savale, P. Boyer, A. Guichard, L. Cedard, A. M. Comaru-Schally, Andrew V Schally

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

In women undergoing in-vitro fertilization and embryo transfer (IVF-ET), a total of 408 IVF cycles were stimulated using human menopausal gonadotrophin (HMG) or pure follicle stimulating hormone (FSH) plus HMG in combination with a single injection of D-Trp6-LHRH microcapsules in order to enhance the ovarian response to gonadotrophins and to avoid spontaneous LH surges. Sixty-seven pregnancies were achieved. Two protocols were employed. In protocol 1 ('blocking protocol', n = 268), the pituitary was first inhibited with a full dose (3.75 mg) of D-Trp6-LHRH in microcapsules and ovarian stimulation was started after the hypogonadotrophic hypogonadal state was ascertained (E2 <50 pg/ml). In protocol 2 ('flare-up protocol', n = 140), the treatment with D-Trp6-LHRH microcapsules (half-dose = 1.80 mg) and the ovarian stimulation with gonadotrophins were started at the same time. Higher doses of gonadotrophins were needed (39.5 ± 11.2 ampoules FSH and/or HMG) in protocol 1, in which the pituitary was blocked prior to and during the stimulation, than in protocol 2 (20 ± 9 ampoules) where the exogenous gonadotrophin stimulation appeared to be augmented by the initial agonistic effect of the injection of D-Trp6-LHRH microcapsules. In patients with purely tubal infertility, under 38 years old and no male factor, the results obtained with protocols 1 and 2 were similar in terms of pregnancy rate per cycle or per embryo transfer: 22.6 versus 20.5% and 28.3 versus 27.4%, respectively. However, considering the cost benefit, 'flare-up' protocols appeared to be a better choice and could be recommended.

Original languageEnglish
Pages (from-to)235-239
Number of pages5
JournalHuman Reproduction
Volume3
Issue number2
StatePublished - Jan 1 1988
Externally publishedYes

Fingerprint

Ovarian Stimulation
Pituitary Gonadotropins
Gonadotropins
In Vitro Fertilization
Ovulation Induction
Fertilization in Vitro
Menotropins
Gonadotropin-Releasing Hormone
Capsules
Embryo Transfer
Follicle Stimulating Hormone
Hormones
Injections
Flare
Dose
Pregnancy Rate
Pregnancy
Infertility
Cost-Benefit Analysis
Injection

ASJC Scopus subject areas

  • Developmental Biology
  • Physiology
  • Obstetrics and Gynecology
  • Reproductive Medicine
  • Statistics, Probability and Uncertainty
  • Applied Mathematics
  • Physiology (medical)
  • Rehabilitation

Cite this

Ovarian stimulation for in-vitro fertilization combining administration of gonadotrophins and blockade of the pituitary with D-Trp6-LHRH microcapsules : Pilot studies with two protocols. / Zorn, J. R.; Barata, M.; Brami, C.; Epelboin, S.; Nathan, C.; Papageorgiou, G.; Quantin, P.; Rolet, F.; Savale, M.; Boyer, P.; Guichard, A.; Cedard, L.; Comaru-Schally, A. M.; Schally, Andrew V.

In: Human Reproduction, Vol. 3, No. 2, 01.01.1988, p. 235-239.

Research output: Contribution to journalArticle

Zorn, JR, Barata, M, Brami, C, Epelboin, S, Nathan, C, Papageorgiou, G, Quantin, P, Rolet, F, Savale, M, Boyer, P, Guichard, A, Cedard, L, Comaru-Schally, AM & Schally, AV 1988, 'Ovarian stimulation for in-vitro fertilization combining administration of gonadotrophins and blockade of the pituitary with D-Trp6-LHRH microcapsules: Pilot studies with two protocols', Human Reproduction, vol. 3, no. 2, pp. 235-239.
Zorn, J. R. ; Barata, M. ; Brami, C. ; Epelboin, S. ; Nathan, C. ; Papageorgiou, G. ; Quantin, P. ; Rolet, F. ; Savale, M. ; Boyer, P. ; Guichard, A. ; Cedard, L. ; Comaru-Schally, A. M. ; Schally, Andrew V. / Ovarian stimulation for in-vitro fertilization combining administration of gonadotrophins and blockade of the pituitary with D-Trp6-LHRH microcapsules : Pilot studies with two protocols. In: Human Reproduction. 1988 ; Vol. 3, No. 2. pp. 235-239.
@article{c0d217e5cc7c4f3bbc154a54398331d1,
title = "Ovarian stimulation for in-vitro fertilization combining administration of gonadotrophins and blockade of the pituitary with D-Trp6-LHRH microcapsules: Pilot studies with two protocols",
abstract = "In women undergoing in-vitro fertilization and embryo transfer (IVF-ET), a total of 408 IVF cycles were stimulated using human menopausal gonadotrophin (HMG) or pure follicle stimulating hormone (FSH) plus HMG in combination with a single injection of D-Trp6-LHRH microcapsules in order to enhance the ovarian response to gonadotrophins and to avoid spontaneous LH surges. Sixty-seven pregnancies were achieved. Two protocols were employed. In protocol 1 ('blocking protocol', n = 268), the pituitary was first inhibited with a full dose (3.75 mg) of D-Trp6-LHRH in microcapsules and ovarian stimulation was started after the hypogonadotrophic hypogonadal state was ascertained (E2 <50 pg/ml). In protocol 2 ('flare-up protocol', n = 140), the treatment with D-Trp6-LHRH microcapsules (half-dose = 1.80 mg) and the ovarian stimulation with gonadotrophins were started at the same time. Higher doses of gonadotrophins were needed (39.5 ± 11.2 ampoules FSH and/or HMG) in protocol 1, in which the pituitary was blocked prior to and during the stimulation, than in protocol 2 (20 ± 9 ampoules) where the exogenous gonadotrophin stimulation appeared to be augmented by the initial agonistic effect of the injection of D-Trp6-LHRH microcapsules. In patients with purely tubal infertility, under 38 years old and no male factor, the results obtained with protocols 1 and 2 were similar in terms of pregnancy rate per cycle or per embryo transfer: 22.6 versus 20.5{\%} and 28.3 versus 27.4{\%}, respectively. However, considering the cost benefit, 'flare-up' protocols appeared to be a better choice and could be recommended.",
author = "Zorn, {J. R.} and M. Barata and C. Brami and S. Epelboin and C. Nathan and G. Papageorgiou and P. Quantin and F. Rolet and M. Savale and P. Boyer and A. Guichard and L. Cedard and Comaru-Schally, {A. M.} and Schally, {Andrew V}",
year = "1988",
month = "1",
day = "1",
language = "English",
volume = "3",
pages = "235--239",
journal = "Human Reproduction",
issn = "0268-1161",
publisher = "Oxford University Press",
number = "2",

}

TY - JOUR

T1 - Ovarian stimulation for in-vitro fertilization combining administration of gonadotrophins and blockade of the pituitary with D-Trp6-LHRH microcapsules

T2 - Pilot studies with two protocols

AU - Zorn, J. R.

AU - Barata, M.

AU - Brami, C.

AU - Epelboin, S.

AU - Nathan, C.

AU - Papageorgiou, G.

AU - Quantin, P.

AU - Rolet, F.

AU - Savale, M.

AU - Boyer, P.

AU - Guichard, A.

AU - Cedard, L.

AU - Comaru-Schally, A. M.

AU - Schally, Andrew V

PY - 1988/1/1

Y1 - 1988/1/1

N2 - In women undergoing in-vitro fertilization and embryo transfer (IVF-ET), a total of 408 IVF cycles were stimulated using human menopausal gonadotrophin (HMG) or pure follicle stimulating hormone (FSH) plus HMG in combination with a single injection of D-Trp6-LHRH microcapsules in order to enhance the ovarian response to gonadotrophins and to avoid spontaneous LH surges. Sixty-seven pregnancies were achieved. Two protocols were employed. In protocol 1 ('blocking protocol', n = 268), the pituitary was first inhibited with a full dose (3.75 mg) of D-Trp6-LHRH in microcapsules and ovarian stimulation was started after the hypogonadotrophic hypogonadal state was ascertained (E2 <50 pg/ml). In protocol 2 ('flare-up protocol', n = 140), the treatment with D-Trp6-LHRH microcapsules (half-dose = 1.80 mg) and the ovarian stimulation with gonadotrophins were started at the same time. Higher doses of gonadotrophins were needed (39.5 ± 11.2 ampoules FSH and/or HMG) in protocol 1, in which the pituitary was blocked prior to and during the stimulation, than in protocol 2 (20 ± 9 ampoules) where the exogenous gonadotrophin stimulation appeared to be augmented by the initial agonistic effect of the injection of D-Trp6-LHRH microcapsules. In patients with purely tubal infertility, under 38 years old and no male factor, the results obtained with protocols 1 and 2 were similar in terms of pregnancy rate per cycle or per embryo transfer: 22.6 versus 20.5% and 28.3 versus 27.4%, respectively. However, considering the cost benefit, 'flare-up' protocols appeared to be a better choice and could be recommended.

AB - In women undergoing in-vitro fertilization and embryo transfer (IVF-ET), a total of 408 IVF cycles were stimulated using human menopausal gonadotrophin (HMG) or pure follicle stimulating hormone (FSH) plus HMG in combination with a single injection of D-Trp6-LHRH microcapsules in order to enhance the ovarian response to gonadotrophins and to avoid spontaneous LH surges. Sixty-seven pregnancies were achieved. Two protocols were employed. In protocol 1 ('blocking protocol', n = 268), the pituitary was first inhibited with a full dose (3.75 mg) of D-Trp6-LHRH in microcapsules and ovarian stimulation was started after the hypogonadotrophic hypogonadal state was ascertained (E2 <50 pg/ml). In protocol 2 ('flare-up protocol', n = 140), the treatment with D-Trp6-LHRH microcapsules (half-dose = 1.80 mg) and the ovarian stimulation with gonadotrophins were started at the same time. Higher doses of gonadotrophins were needed (39.5 ± 11.2 ampoules FSH and/or HMG) in protocol 1, in which the pituitary was blocked prior to and during the stimulation, than in protocol 2 (20 ± 9 ampoules) where the exogenous gonadotrophin stimulation appeared to be augmented by the initial agonistic effect of the injection of D-Trp6-LHRH microcapsules. In patients with purely tubal infertility, under 38 years old and no male factor, the results obtained with protocols 1 and 2 were similar in terms of pregnancy rate per cycle or per embryo transfer: 22.6 versus 20.5% and 28.3 versus 27.4%, respectively. However, considering the cost benefit, 'flare-up' protocols appeared to be a better choice and could be recommended.

UR - http://www.scopus.com/inward/record.url?scp=0023857143&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023857143&partnerID=8YFLogxK

M3 - Article

C2 - 2965712

AN - SCOPUS:0023857143

VL - 3

SP - 235

EP - 239

JO - Human Reproduction

JF - Human Reproduction

SN - 0268-1161

IS - 2

ER -