Ovarian complete hydatidiform mole: Case study with molecular analysis and review of the literature

Jennifer K. Sehn, Lindsay M. Kuroki, Margaret M. Hopeman, Ryan E Longman, Colleen P. McNicholas, Phyllis C. Huettner

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Ectopic complete molar pregnancy in the ovary is an exceptionally rare event. Here we present a case of ovarian complete hydatidiform mole in a 20-year-old gravida 2 para 1 woman. At presentation, the patient underwent excision of a hemorrhagic left ovarian cyst, with routine sections demonstrating a hemorrhagic corpus luteum with a single microscopic focus of detached atypical trophoblast, without chorionic villi. Subsequent left salpingo-oophorectomy for persistently elevated human chorionic gonadotropin led to a final diagnosis of complete hydatidiform mole arising in the ovary. The fallopian tube was unremarkable. Zygosity was determined using short tandem repeat analysis, confirming the diagnosis of monospermic complete mole. In the clinical setting of a markedly elevated human chorionic gonadotropin level and an ovarian mass, histopathologic examination is critical in distinguishing ectopic pregnancy from choriocarcinoma. Short tandem repeat analysis can be a useful adjunct to histologic diagnosis in challenging cases.

Original languageEnglish (US)
Pages (from-to)2861-2864
Number of pages4
JournalHuman Pathology
Volume44
Issue number12
DOIs
StatePublished - Dec 2013
Externally publishedYes

Fingerprint

Hydatidiform Mole
Chorionic Gonadotropin
Microsatellite Repeats
Ovary
Chorionic Villi
Ovarian Cysts
Choriocarcinoma
Fallopian Tubes
Ectopic Pregnancy
Corpus Luteum
Trophoblasts
Ovariectomy

Keywords

  • Complete mole
  • Ectopic pregnancy
  • Hydatidiform mole
  • Ovary
  • STR

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Ovarian complete hydatidiform mole : Case study with molecular analysis and review of the literature. / Sehn, Jennifer K.; Kuroki, Lindsay M.; Hopeman, Margaret M.; Longman, Ryan E; McNicholas, Colleen P.; Huettner, Phyllis C.

In: Human Pathology, Vol. 44, No. 12, 12.2013, p. 2861-2864.

Research output: Contribution to journalArticle

Sehn, Jennifer K. ; Kuroki, Lindsay M. ; Hopeman, Margaret M. ; Longman, Ryan E ; McNicholas, Colleen P. ; Huettner, Phyllis C. / Ovarian complete hydatidiform mole : Case study with molecular analysis and review of the literature. In: Human Pathology. 2013 ; Vol. 44, No. 12. pp. 2861-2864.
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