Ovarian cancer: The fallopian tube as the site of origin and opportunities for prevention

Research output: Contribution to journalReview articlepeer-review

41 Scopus citations


High-grade serous carcinoma (HGSC) is the most common and aggressive histotype of epithelial ovarian cancer (EOC), and it is the predominant histotype associated with hereditary breast and ovarian cancer syndrome (HBOC). Mutations in BRCA1 and BRCA2 are responsible for most of the known causes of HBOC, while mutations in mismatch repair genes and several genes of moderate penetrance are responsible for the remaining known hereditary risk. Women with a history of familial ovarian cancer or with known germline mutations in highly penetrant genes are offered the option of risk-reducing surgery that involves the removal of the ovaries and fallopian tubes (salpingo-oophorectomy). Growing evidence now supports the fallopian tube epithelia as an etiological site for the development of HGSC and consequently, salpingectomy alone is emerging as a prophylactic option. This review discusses the site of origin of EOC, the rationale for risk-reducing salpingectomy in the high-risk population, and opportunities for salpingectomy in the low-risk population.

Original languageEnglish (US)
Article number108
JournalFrontiers in Oncology
Issue numberMAY
StatePublished - 2016


  • BRCA1
  • BRCA2
  • Fallopian tubes
  • Ovarian cancers
  • Salpingectomy

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


Dive into the research topics of 'Ovarian cancer: The fallopian tube as the site of origin and opportunities for prevention'. Together they form a unique fingerprint.

Cite this