Ovarian ageing, follicle depletion, and cancer: a hypothesis for the aetiology of epithelial ovarian cancer involving follicle depletion

Elizabeth R. Smith, Xiang Xi Xu

Research output: Contribution to journalComment/debate

34 Scopus citations

Abstract

The association between ovarian cancer risk and reproductive factors has been well established, and two main theories, incessant ovulation and gonadotropin stimulation, have been proposed to explain the mechanism. Recent studies using animal models of ovarian tumorigenesis, and analysis of ovarian tissues from prophylactic oophorectomies, suggest that depletion of ovarian follicles might underlie the epidemiological findings linking reproductive history and ovarian cancer risk.

Original languageEnglish (US)
Pages (from-to)1108-1111
Number of pages4
JournalThe Lancet Oncology
Volume9
Issue number11
DOIs
StatePublished - Nov 2008

ASJC Scopus subject areas

  • Oncology

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