Outcomes of very low birth weight twins cared for in the National Institute of Child Health and Human Development Neonatal Research Network's intensive care units

E. F. Donovan, R. A. Ehrenkranz, S. Shankaran, D. K. Stevenson, L. L. Wright, N. Younes, A. A. Fanaroff, S. B. Korones, B. J. Stoll, J. E. Tyson, Charles R Bauer, J. A. Lemons, W. Oh, L. A. Papile

Research output: Contribution to journalArticle

72 Citations (Scopus)

Abstract

OBJECTIVE: The study's aim was to compare outcomes of very low birth weight twins with those of matched singletons. STUDY DESIGN: With data from the Neonatal Research Network registry (May 1991 to December 1994), univariable and multivariable comparisons of very low birth weight twin pairs and singletons were performed in 2 subgroups: (1) all paired twins and singletons with birth weights between 401 and 1500 g and (2) all paired twins and singletons born at <28 weeks' gestation. RESULTS: Twins constituted 19% of infants admitted with very low birth weight. Mothers of twins were more likely to receive prenatal care, have labor, have cesarean delivery, and receive antenatal glucocorticoids. Twins were more likely to have respiratory disease and to receive surfactant. Second-born twins had more early respiratory disease but similar longer-term outcomes. The risks of death, chronic lung disease, and grade III or IV intracranial hemorrhage were similar in twins and singletons. CONCLUSIONS: Although very low birth weight twins compose a sizable proportion of admissions, in National Institute of Child Health and Human Development Neonatal Research Network intensive care units, twins and singletons have similar outcomes.

Original languageEnglish
Pages (from-to)742-749
Number of pages8
JournalAmerican Journal of Obstetrics and Gynecology
Volume179
Issue number3 I
DOIs
StatePublished - Oct 12 1998
Externally publishedYes

Fingerprint

National Institute of Child Health and Human Development (U.S.)
Very Low Birth Weight Infant
Intensive Care Units
Research
Prenatal Care
Intracranial Hemorrhages
Birth Weight
Surface-Active Agents
Glucocorticoids
Lung Diseases
Registries

Keywords

  • Morbidity
  • Mortality
  • Twins
  • Very low birth weight

ASJC Scopus subject areas

  • Medicine(all)
  • Obstetrics and Gynecology

Cite this

Outcomes of very low birth weight twins cared for in the National Institute of Child Health and Human Development Neonatal Research Network's intensive care units. / Donovan, E. F.; Ehrenkranz, R. A.; Shankaran, S.; Stevenson, D. K.; Wright, L. L.; Younes, N.; Fanaroff, A. A.; Korones, S. B.; Stoll, B. J.; Tyson, J. E.; Bauer, Charles R; Lemons, J. A.; Oh, W.; Papile, L. A.

In: American Journal of Obstetrics and Gynecology, Vol. 179, No. 3 I, 12.10.1998, p. 742-749.

Research output: Contribution to journalArticle

Donovan, EF, Ehrenkranz, RA, Shankaran, S, Stevenson, DK, Wright, LL, Younes, N, Fanaroff, AA, Korones, SB, Stoll, BJ, Tyson, JE, Bauer, CR, Lemons, JA, Oh, W & Papile, LA 1998, 'Outcomes of very low birth weight twins cared for in the National Institute of Child Health and Human Development Neonatal Research Network's intensive care units', American Journal of Obstetrics and Gynecology, vol. 179, no. 3 I, pp. 742-749. https://doi.org/10.1016/S0002-9378(98)70075-4
Donovan, E. F. ; Ehrenkranz, R. A. ; Shankaran, S. ; Stevenson, D. K. ; Wright, L. L. ; Younes, N. ; Fanaroff, A. A. ; Korones, S. B. ; Stoll, B. J. ; Tyson, J. E. ; Bauer, Charles R ; Lemons, J. A. ; Oh, W. ; Papile, L. A. / Outcomes of very low birth weight twins cared for in the National Institute of Child Health and Human Development Neonatal Research Network's intensive care units. In: American Journal of Obstetrics and Gynecology. 1998 ; Vol. 179, No. 3 I. pp. 742-749.
@article{b82e576c05a44da4aba389ceef08bc94,
title = "Outcomes of very low birth weight twins cared for in the National Institute of Child Health and Human Development Neonatal Research Network's intensive care units",
abstract = "OBJECTIVE: The study's aim was to compare outcomes of very low birth weight twins with those of matched singletons. STUDY DESIGN: With data from the Neonatal Research Network registry (May 1991 to December 1994), univariable and multivariable comparisons of very low birth weight twin pairs and singletons were performed in 2 subgroups: (1) all paired twins and singletons with birth weights between 401 and 1500 g and (2) all paired twins and singletons born at <28 weeks' gestation. RESULTS: Twins constituted 19{\%} of infants admitted with very low birth weight. Mothers of twins were more likely to receive prenatal care, have labor, have cesarean delivery, and receive antenatal glucocorticoids. Twins were more likely to have respiratory disease and to receive surfactant. Second-born twins had more early respiratory disease but similar longer-term outcomes. The risks of death, chronic lung disease, and grade III or IV intracranial hemorrhage were similar in twins and singletons. CONCLUSIONS: Although very low birth weight twins compose a sizable proportion of admissions, in National Institute of Child Health and Human Development Neonatal Research Network intensive care units, twins and singletons have similar outcomes.",
keywords = "Morbidity, Mortality, Twins, Very low birth weight",
author = "Donovan, {E. F.} and Ehrenkranz, {R. A.} and S. Shankaran and Stevenson, {D. K.} and Wright, {L. L.} and N. Younes and Fanaroff, {A. A.} and Korones, {S. B.} and Stoll, {B. J.} and Tyson, {J. E.} and Bauer, {Charles R} and Lemons, {J. A.} and W. Oh and Papile, {L. A.}",
year = "1998",
month = "10",
day = "12",
doi = "10.1016/S0002-9378(98)70075-4",
language = "English",
volume = "179",
pages = "742--749",
journal = "American Journal of Obstetrics and Gynecology",
issn = "0002-9378",
publisher = "Mosby Inc.",
number = "3 I",

}

TY - JOUR

T1 - Outcomes of very low birth weight twins cared for in the National Institute of Child Health and Human Development Neonatal Research Network's intensive care units

AU - Donovan, E. F.

AU - Ehrenkranz, R. A.

AU - Shankaran, S.

AU - Stevenson, D. K.

AU - Wright, L. L.

AU - Younes, N.

AU - Fanaroff, A. A.

AU - Korones, S. B.

AU - Stoll, B. J.

AU - Tyson, J. E.

AU - Bauer, Charles R

AU - Lemons, J. A.

AU - Oh, W.

AU - Papile, L. A.

PY - 1998/10/12

Y1 - 1998/10/12

N2 - OBJECTIVE: The study's aim was to compare outcomes of very low birth weight twins with those of matched singletons. STUDY DESIGN: With data from the Neonatal Research Network registry (May 1991 to December 1994), univariable and multivariable comparisons of very low birth weight twin pairs and singletons were performed in 2 subgroups: (1) all paired twins and singletons with birth weights between 401 and 1500 g and (2) all paired twins and singletons born at <28 weeks' gestation. RESULTS: Twins constituted 19% of infants admitted with very low birth weight. Mothers of twins were more likely to receive prenatal care, have labor, have cesarean delivery, and receive antenatal glucocorticoids. Twins were more likely to have respiratory disease and to receive surfactant. Second-born twins had more early respiratory disease but similar longer-term outcomes. The risks of death, chronic lung disease, and grade III or IV intracranial hemorrhage were similar in twins and singletons. CONCLUSIONS: Although very low birth weight twins compose a sizable proportion of admissions, in National Institute of Child Health and Human Development Neonatal Research Network intensive care units, twins and singletons have similar outcomes.

AB - OBJECTIVE: The study's aim was to compare outcomes of very low birth weight twins with those of matched singletons. STUDY DESIGN: With data from the Neonatal Research Network registry (May 1991 to December 1994), univariable and multivariable comparisons of very low birth weight twin pairs and singletons were performed in 2 subgroups: (1) all paired twins and singletons with birth weights between 401 and 1500 g and (2) all paired twins and singletons born at <28 weeks' gestation. RESULTS: Twins constituted 19% of infants admitted with very low birth weight. Mothers of twins were more likely to receive prenatal care, have labor, have cesarean delivery, and receive antenatal glucocorticoids. Twins were more likely to have respiratory disease and to receive surfactant. Second-born twins had more early respiratory disease but similar longer-term outcomes. The risks of death, chronic lung disease, and grade III or IV intracranial hemorrhage were similar in twins and singletons. CONCLUSIONS: Although very low birth weight twins compose a sizable proportion of admissions, in National Institute of Child Health and Human Development Neonatal Research Network intensive care units, twins and singletons have similar outcomes.

KW - Morbidity

KW - Mortality

KW - Twins

KW - Very low birth weight

UR - http://www.scopus.com/inward/record.url?scp=0031716539&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0031716539&partnerID=8YFLogxK

U2 - 10.1016/S0002-9378(98)70075-4

DO - 10.1016/S0002-9378(98)70075-4

M3 - Article

C2 - 9757982

AN - SCOPUS:0031716539

VL - 179

SP - 742

EP - 749

JO - American Journal of Obstetrics and Gynecology

JF - American Journal of Obstetrics and Gynecology

SN - 0002-9378

IS - 3 I

ER -