Outcomes of organ transplants when the donor is a prior recipient

G. S. Lee, D. S. Goldberg, M. H. Levine, P. L. Abt

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Organ shortage continues to challenge the field of transplantation. One potential group of donors are those who have been transplant recipients themselves, or Organ Donation After Transplant (ODAT) donors. We conducted a retrospective cohort study to describe ODAT donors and to compare outcomes of ODAT grafts versus conventional grafts. From October 1, 1987 to June 30, 2015, 517 former recipients successfully donated 803 organs for transplant. Former kidney recipients generally survived a median of approximately 4 years before becoming an ODAT donor whereas liver, lung, and heart recipients generally survived less than a month prior to donation. In the period June 1, 2005 to December 31, 2014, liver grafts from ODAT donors had a significantly higher risk of graft failure compared to non-ODAT liver transplants (P =.008). Kidney grafts donated by ODAT donors whose initial transplant occurred >1 year prior were associated with significantly increased graft failure (P =.012). Despite increased risk of graft failure amongst certain ODAT grafts, 5-year survival was still high. ODAT donors should be considered another form of expanded criteria donor under these circumstances.

Original languageEnglish (US)
Pages (from-to)492-503
Number of pages12
JournalAmerican Journal of Transplantation
Volume18
Issue number2
DOIs
StatePublished - Feb 2018
Externally publishedYes

Keywords

  • clinical research/practice
  • donors and donation
  • donors and donation: extended criteria
  • graft survival
  • health services and outcomes research
  • organ acceptance
  • organ allocation
  • organ procurement and allocation
  • organ transplantation in general

ASJC Scopus subject areas

  • Immunology and Allergy
  • Transplantation
  • Pharmacology (medical)

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