Outcomes in liver transplant recipients with hepatitis B virus: Resistance and recurrence patterns from a large transplant center over the last decade

Guy W. Neff, Christopher B. O'Brien, Jose Nery, Norah Shire, Marzia Montalbano, Phillip Ruiz, Ciao Nery, Kamran Safdar, Maria De Medina, Andreas G. Tzakis, Eugene R. Schiff, Juan Madariaga

Research output: Contribution to journalArticle

81 Scopus citations

Abstract

Hepatitis B virus (HBV) recurrence following liver transplantation (LTx) has been controllable primarily with the use of hepatitis B immune globulin (HBIg) and lamivudine (LAM). However, HBV resistance to LAM and/or HBIg has become an increasing problem prompting the use of newer antiviral agents. The purpose of our study was to investigate the association between therapy, HBV breakthrough, and allograft / patient survival in HBV-positive liver transplant recipients. We performed a retrospective review of the medical records of patients that were transplanted for HBV from June 1994 to May 2003. A total of 92 patients, positive for either hepatitis B surface antigen (HBsAg) or HBV deoxyribonucleic acid (DNA) pretransplant, received LAM monotherapy or HBIg (6 months) plus LAM therapy post-liver transplant. HBV breakthrough post-LTx was noted in 14 patients. All patients had detectable HBV DNA prior to liver transplantation; none of the patients that were HBV DNA negative prior to transplant had detectable HBV DNA posttransplant. Of these 14, 9 patients (64%) were switched from LAM to adefovir dipivoxil (ADF) and 5 patients (36%) to tenofovir disoproxil fumarate (TNV). In conclusion, pre-LTx HBV viremia should be considered in planning post-LTx prophylaxis. Trials to evaluate oral antiviral agents in combination with or without HBIg therapy are needed.

Original languageEnglish (US)
Pages (from-to)1372-1378
Number of pages7
JournalLiver Transplantation
Volume10
Issue number11
DOIs
StatePublished - Nov 1 2004

ASJC Scopus subject areas

  • Surgery
  • Hepatology
  • Transplantation

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