Outcome variables for osteoarthritis clinical trials: The OMERACT-OARSI set of responder criteria

Thao Pham, Désirée Van Der Heijde, Marissa Lassere, Roy D. Altman, Jennifer J. Anderson, Nicholas Bellamy, Marc Hochberg, Lee Simon, Vibeke Strand, Thasia Woodworth, Maxime Dougados

Research output: Contribution to journalArticle

186 Scopus citations

Abstract

Improvement in analysis and reporting results of osteoarthritis (OA) clinical trials has been recently obtained because of harmonization and standardization of the selection of outcome variables (OMERACT 3 and OARSI). Moreover, OARSI has recently proposed the OARSI responder criteria. This composite index permits presentation of results of symptom modifying clinical trials in OA based on individual patient responses (responder yes/no). The 2 organizations (OMERACT and OARSI) established a task force aimed at evaluating: (1) the variability of observed placebo and active treatment effects using the OARSI responder criteria; and (2) the possibility of proposing a simplified set of criteria. The conclusions of the task force were presented and discussed during the OMERACT 6 conference, where a simplified set of responder criteria (OMERACT-OARSI set of criteria) was proposed.

Original languageEnglish (US)
Pages (from-to)1648-1654
Number of pages7
JournalJournal of Rheumatology
Volume30
Issue number7
StatePublished - Jul 1 2003

Keywords

  • Clinical responder criteria
  • Osteoarthritis
  • Outcomes

ASJC Scopus subject areas

  • Rheumatology
  • Immunology and Allergy
  • Immunology

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    Pham, T., Der Heijde, D. V., Lassere, M., Altman, R. D., Anderson, J. J., Bellamy, N., Hochberg, M., Simon, L., Strand, V., Woodworth, T., & Dougados, M. (2003). Outcome variables for osteoarthritis clinical trials: The OMERACT-OARSI set of responder criteria. Journal of Rheumatology, 30(7), 1648-1654.