Outcome of treatment of MDR-TB patients with standardised regimens, Iran, 2002-2006

M. R. Masjedi, Payam Tabarsi, E. Chitsaz, P. Baghaei, M. Mirsaeidi, M. V. Amiri, P. Farnia, P. Javanmard, D. Mansouri, A. A. Velayati

Research output: Contribution to journalArticle

48 Scopus citations

Abstract

BACKGROUND: Multidrug-resistant tuberculosis (MDR-TB) imposes a formidable burden on national health systems. There is still no consensus on the subject, with controversies regarding treatment protocols, treatment outcomes and the various treatment regimens. METHODS: The present study describes Iran's second national cohort for treatment of MDR-TB. The study comprised all documented MDR-TB cases in Iran referred to our centre during the period 2002-2006. All patients received a standardised second-line regimen consisting of ofloxacin, cycloserine, prothionamide and amikacin. Based on drug susceptibility testing results, ethambutol and pyrazinamide were added to the regimen. RESULTS: Forty-three patients diagnosed with MDR-TB, with a mean age of 44.38 ± 19.05 years, received treatment; of these, 27 (62.8%) were male. Twenty-three were (53.5%) Iranians and the remainder were Afghans. All patients were acquired MDR-TB cases. Of the 43 cases, 25 (58.1%) experienced severe clinically significant adverse effects; 29 (67.5%) had a successful outcome and 14 (32.5%) had a poor outcome (treatment failure in six [14%] and death in eight [18.6%]). Mortality was higher in Iranians (P = 0.039) and in patients whose initial regimen was changed due to adverse drug reactions (P = 0.01). CONCLUSION: Compared with previous studies, our study was able to obtain more favourable outcomes of MDR-TB treatment using a standardised regimen.

Original languageEnglish (US)
Pages (from-to)750-755
Number of pages6
JournalInternational Journal of Tuberculosis and Lung Disease
Volume12
Issue number7
StatePublished - Jul 1 2008
Externally publishedYes

Keywords

  • Iran
  • MDR-TB
  • Standardised regimen
  • Treatment outcome

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Infectious Diseases

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    Masjedi, M. R., Tabarsi, P., Chitsaz, E., Baghaei, P., Mirsaeidi, M., Amiri, M. V., Farnia, P., Javanmard, P., Mansouri, D., & Velayati, A. A. (2008). Outcome of treatment of MDR-TB patients with standardised regimens, Iran, 2002-2006. International Journal of Tuberculosis and Lung Disease, 12(7), 750-755.