Outcome measures in spinal cord injury: Recent assessments and recommendations for future directions

M. S. Alexander, Kimberly D Anderson, F. Biering-Sorensen, A. R. Blight, R. Brannon, T. N. Bryce, G. Creasey, A. Catz, A. Curt, W. Donovan, J. Ditunno, P. Ellaway, N. B. Finnerup, D. E. Graves, B. A. Haynes, A. W. Heinemann, A. B. Jackson, M. V. Johnston, C. Z. Kalpakjian, N. KleitmanA. Krassioukov, K. Krogh, D. Lammertse, S. Magasi, M. J. Mulcahey, B. Schurch, A. Sherwood, J. D. Steeves, S. Stiens, D. S. Tulsky, H. J A Van Hedel, G. Whiteneck

Research output: Contribution to journalArticle

124 Citations (Scopus)

Abstract

Study design: Review by the spinal cord outcomes partnership endeavor (SCOPE), which is a broad-based international consortium of scientists and clinical researchers representing academic institutions, industry, government agencies, not-for-profit organizations and foundations. Objectives: Assessment of current and evolving tools for evaluating human spinal cord injury (SCI) outcomes for both clinical diagnosis and clinical research studies. Methods: a framework for the appraisal of evidence of metric properties was used to examine outcome tools or tests for accuracy, sensitivity, reliability and validity for human SCI. Results: Imaging, neurological, functional, autonomic, sexual health, bladder/bowel, pain and psychosocial tools were evaluated. Several specific tools for human SCI studies have or are being developed to allow the more accurate determination for a clinically meaningful benefit (improvement in functional outcome or quality of life) being achieved as a result of a therapeutic intervention. Conclusion: Significant progress has been made, but further validation studies are required to identify the most appropriate tools for specific targets in a human SCI study or clinical trial.

Original languageEnglish
Pages (from-to)582-591
Number of pages10
JournalSpinal Cord
Volume47
Issue number8
DOIs
StatePublished - Aug 1 2009
Externally publishedYes

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Spinal Cord Injuries
Outcome Assessment (Health Care)
Government Agencies
Validation Studies
Reproductive Health
Reproducibility of Results
Spinal Cord
Industry
Urinary Bladder
Quality of Life
Research Personnel
Clinical Trials
Organizations
Pain
Direction compound
Research
Therapeutics

Keywords

  • Diagnostic tools
  • Functional assessment
  • Outcome tools
  • Quality of life and community participation
  • Spinal cord clinical trial targets
  • Upper and lower limb

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

Cite this

Alexander, M. S., Anderson, K. D., Biering-Sorensen, F., Blight, A. R., Brannon, R., Bryce, T. N., ... Whiteneck, G. (2009). Outcome measures in spinal cord injury: Recent assessments and recommendations for future directions. Spinal Cord, 47(8), 582-591. https://doi.org/10.1038/sc.2009.18

Outcome measures in spinal cord injury : Recent assessments and recommendations for future directions. / Alexander, M. S.; Anderson, Kimberly D; Biering-Sorensen, F.; Blight, A. R.; Brannon, R.; Bryce, T. N.; Creasey, G.; Catz, A.; Curt, A.; Donovan, W.; Ditunno, J.; Ellaway, P.; Finnerup, N. B.; Graves, D. E.; Haynes, B. A.; Heinemann, A. W.; Jackson, A. B.; Johnston, M. V.; Kalpakjian, C. Z.; Kleitman, N.; Krassioukov, A.; Krogh, K.; Lammertse, D.; Magasi, S.; Mulcahey, M. J.; Schurch, B.; Sherwood, A.; Steeves, J. D.; Stiens, S.; Tulsky, D. S.; Van Hedel, H. J A; Whiteneck, G.

In: Spinal Cord, Vol. 47, No. 8, 01.08.2009, p. 582-591.

Research output: Contribution to journalArticle

Alexander, MS, Anderson, KD, Biering-Sorensen, F, Blight, AR, Brannon, R, Bryce, TN, Creasey, G, Catz, A, Curt, A, Donovan, W, Ditunno, J, Ellaway, P, Finnerup, NB, Graves, DE, Haynes, BA, Heinemann, AW, Jackson, AB, Johnston, MV, Kalpakjian, CZ, Kleitman, N, Krassioukov, A, Krogh, K, Lammertse, D, Magasi, S, Mulcahey, MJ, Schurch, B, Sherwood, A, Steeves, JD, Stiens, S, Tulsky, DS, Van Hedel, HJA & Whiteneck, G 2009, 'Outcome measures in spinal cord injury: Recent assessments and recommendations for future directions', Spinal Cord, vol. 47, no. 8, pp. 582-591. https://doi.org/10.1038/sc.2009.18
Alexander MS, Anderson KD, Biering-Sorensen F, Blight AR, Brannon R, Bryce TN et al. Outcome measures in spinal cord injury: Recent assessments and recommendations for future directions. Spinal Cord. 2009 Aug 1;47(8):582-591. https://doi.org/10.1038/sc.2009.18
Alexander, M. S. ; Anderson, Kimberly D ; Biering-Sorensen, F. ; Blight, A. R. ; Brannon, R. ; Bryce, T. N. ; Creasey, G. ; Catz, A. ; Curt, A. ; Donovan, W. ; Ditunno, J. ; Ellaway, P. ; Finnerup, N. B. ; Graves, D. E. ; Haynes, B. A. ; Heinemann, A. W. ; Jackson, A. B. ; Johnston, M. V. ; Kalpakjian, C. Z. ; Kleitman, N. ; Krassioukov, A. ; Krogh, K. ; Lammertse, D. ; Magasi, S. ; Mulcahey, M. J. ; Schurch, B. ; Sherwood, A. ; Steeves, J. D. ; Stiens, S. ; Tulsky, D. S. ; Van Hedel, H. J A ; Whiteneck, G. / Outcome measures in spinal cord injury : Recent assessments and recommendations for future directions. In: Spinal Cord. 2009 ; Vol. 47, No. 8. pp. 582-591.
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