Abstract
Over the past several years, with the evolution of genetic and molecular research, several etiologic factors have been implicated in the pathogenesis of otosclerosis. Overall, current evidence suggests that otosclerosis is a complex disease with a variety of potential pathways contributing to the development of abnormal bone remodeling in the otic capsule. These pathways involved in the pathogenesis of otosclerosis are influenced by both genetic and environmental factors.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 305-318 |
| Number of pages | 14 |
| Journal | Otolaryngologic Clinics of North America |
| Volume | 51 |
| Issue number | 2 |
| DOIs | |
| State | Published - Apr 1 2018 |
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Keywords
- Gene
- Genetics
- Otic capsule
- Otosclerosis
- Pathophysiology
ASJC Scopus subject areas
- Otorhinolaryngology
Cite this
Otosclerosis : From Genetics to Molecular Biology. / Babcock, Thomas A.; Liu, Xue Z.
In: Otolaryngologic Clinics of North America, Vol. 51, No. 2, 01.04.2018, p. 305-318.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Otosclerosis
T2 - From Genetics to Molecular Biology
AU - Babcock, Thomas A.
AU - Liu, Xue Z
PY - 2018/4/1
Y1 - 2018/4/1
N2 - Over the past several years, with the evolution of genetic and molecular research, several etiologic factors have been implicated in the pathogenesis of otosclerosis. Overall, current evidence suggests that otosclerosis is a complex disease with a variety of potential pathways contributing to the development of abnormal bone remodeling in the otic capsule. These pathways involved in the pathogenesis of otosclerosis are influenced by both genetic and environmental factors.
AB - Over the past several years, with the evolution of genetic and molecular research, several etiologic factors have been implicated in the pathogenesis of otosclerosis. Overall, current evidence suggests that otosclerosis is a complex disease with a variety of potential pathways contributing to the development of abnormal bone remodeling in the otic capsule. These pathways involved in the pathogenesis of otosclerosis are influenced by both genetic and environmental factors.
KW - Gene
KW - Genetics
KW - Otic capsule
KW - Otosclerosis
KW - Pathophysiology
UR - http://www.scopus.com/inward/record.url?scp=85042776440&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85042776440&partnerID=8YFLogxK
U2 - 10.1016/j.otc.2017.11.002
DO - 10.1016/j.otc.2017.11.002
M3 - Review article
C2 - 29502723
AN - SCOPUS:85042776440
VL - 51
SP - 305
EP - 318
JO - Otolaryngologic Clinics of North America
JF - Otolaryngologic Clinics of North America
SN - 0030-6665
IS - 2
ER -