Otosclerosis: From Genetics to Molecular Biology

Thomas A. Babcock, Xue Z Liu

Research output: Contribution to journalReview article

9 Scopus citations

Abstract

Over the past several years, with the evolution of genetic and molecular research, several etiologic factors have been implicated in the pathogenesis of otosclerosis. Overall, current evidence suggests that otosclerosis is a complex disease with a variety of potential pathways contributing to the development of abnormal bone remodeling in the otic capsule. These pathways involved in the pathogenesis of otosclerosis are influenced by both genetic and environmental factors.

Original languageEnglish (US)
Pages (from-to)305-318
Number of pages14
JournalOtolaryngologic Clinics of North America
Volume51
Issue number2
DOIs
StatePublished - Apr 1 2018

Keywords

  • Gene
  • Genetics
  • Otic capsule
  • Otosclerosis
  • Pathophysiology

ASJC Scopus subject areas

  • Otorhinolaryngology

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