Otosclerosis: From Genetics to Molecular Biology

Thomas A. Babcock; Xue Zhong Liu

doi:10.1016/j.otc.2017.11.002

Otosclerosis: From Genetics to Molecular Biology

Thomas A. Babcock, Xue Zhong Liu

Otolaryngology

Research output: Contribution to journal › Review article › peer-review

16 Scopus citations

Abstract

Over the past several years, with the evolution of genetic and molecular research, several etiologic factors have been implicated in the pathogenesis of otosclerosis. Overall, current evidence suggests that otosclerosis is a complex disease with a variety of potential pathways contributing to the development of abnormal bone remodeling in the otic capsule. These pathways involved in the pathogenesis of otosclerosis are influenced by both genetic and environmental factors.

Original language	English (US)
Pages (from-to)	305-318
Number of pages	14
Journal	Otolaryngologic Clinics of North America
Volume	51
Issue number	2
DOIs	https://doi.org/10.1016/j.otc.2017.11.002
State	Published - Apr 2018

Keywords

Gene
Genetics
Otic capsule
Otosclerosis
Pathophysiology

ASJC Scopus subject areas

Otorhinolaryngology

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10.1016/j.otc.2017.11.002

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title = "Otosclerosis: From Genetics to Molecular Biology",

abstract = "Over the past several years, with the evolution of genetic and molecular research, several etiologic factors have been implicated in the pathogenesis of otosclerosis. Overall, current evidence suggests that otosclerosis is a complex disease with a variety of potential pathways contributing to the development of abnormal bone remodeling in the otic capsule. These pathways involved in the pathogenesis of otosclerosis are influenced by both genetic and environmental factors.",

keywords = "Gene, Genetics, Otic capsule, Otosclerosis, Pathophysiology",

author = "Babcock, {Thomas A.} and Liu, {Xue Zhong}",

note = "Funding Information: Disclosure Statement: X.Z. Liu's research is supported by R01 DC05575, R01 DC01246, and R01 DC012115 (National Institutes of Health/National Institute on Deafness and Other Communication Disorders). T.A. Babcock has nothing to disclose.",

year = "2018",

month = apr,

doi = "10.1016/j.otc.2017.11.002",

language = "English (US)",

volume = "51",

pages = "305--318",

journal = "Otolaryngologic Clinics of North America",

issn = "0030-6665",

publisher = "W.B. Saunders Ltd",

number = "2",

}

TY - JOUR

T1 - Otosclerosis

T2 - From Genetics to Molecular Biology

AU - Babcock, Thomas A.

AU - Liu, Xue Zhong

N1 - Funding Information: Disclosure Statement: X.Z. Liu's research is supported by R01 DC05575, R01 DC01246, and R01 DC012115 (National Institutes of Health/National Institute on Deafness and Other Communication Disorders). T.A. Babcock has nothing to disclose.

PY - 2018/4

Y1 - 2018/4

N2 - Over the past several years, with the evolution of genetic and molecular research, several etiologic factors have been implicated in the pathogenesis of otosclerosis. Overall, current evidence suggests that otosclerosis is a complex disease with a variety of potential pathways contributing to the development of abnormal bone remodeling in the otic capsule. These pathways involved in the pathogenesis of otosclerosis are influenced by both genetic and environmental factors.

AB - Over the past several years, with the evolution of genetic and molecular research, several etiologic factors have been implicated in the pathogenesis of otosclerosis. Overall, current evidence suggests that otosclerosis is a complex disease with a variety of potential pathways contributing to the development of abnormal bone remodeling in the otic capsule. These pathways involved in the pathogenesis of otosclerosis are influenced by both genetic and environmental factors.

KW - Gene

KW - Genetics

KW - Otic capsule

KW - Otosclerosis

KW - Pathophysiology

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U2 - 10.1016/j.otc.2017.11.002

DO - 10.1016/j.otc.2017.11.002

M3 - Review article

C2 - 29502723

AN - SCOPUS:85042776440

VL - 51

SP - 305

EP - 318

JO - Otolaryngologic Clinics of North America

JF - Otolaryngologic Clinics of North America

SN - 0030-6665

IS - 2

ER -

Otosclerosis: From Genetics to Molecular Biology

Abstract

Keywords

ASJC Scopus subject areas

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