Abstract
Over the past several years, with the evolution of genetic and molecular research, several etiologic factors have been implicated in the pathogenesis of otosclerosis. Overall, current evidence suggests that otosclerosis is a complex disease with a variety of potential pathways contributing to the development of abnormal bone remodeling in the otic capsule. These pathways involved in the pathogenesis of otosclerosis are influenced by both genetic and environmental factors.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 305-318 |
| Number of pages | 14 |
| Journal | Otolaryngologic Clinics of North America |
| Volume | 51 |
| Issue number | 2 |
| DOIs | |
| State | Published - Apr 1 2018 |
Keywords
- Gene
- Genetics
- Otic capsule
- Otosclerosis
- Pathophysiology
ASJC Scopus subject areas
- Otorhinolaryngology
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Babcock, T. A., & Liu, X. Z. (2018). Otosclerosis: From Genetics to Molecular Biology. Otolaryngologic Clinics of North America, 51(2), 305-318. https://doi.org/10.1016/j.otc.2017.11.002