Osteoradionecrosis: A new concept of its pathophysiology

Research output: Contribution to journalArticle

696 Citations (Scopus)

Abstract

The classic sequence in the pathogenesis of osteoradionecrosis of the jaws has been accepted as radiation, trauma, and infection. This paper challenges this sequence and offers a new one more accurately describing the biochemical and cellular pathology. The clinical data are based on 26 consecutive cases of osteoradionecrosis from which 12 en bloc resection specimens were cultured and stained for microorganisms. Review of the histories and treatments, as well as the microbial assays, indicates that microorganisms play only a contaminant role in osteoradionecrosis and that trauma is only one mechanism of tissue breakdown leading to the condition. The sequence suggested by this study is as follows: (1) radiation, (2) hypoxic-hypocellular-hypovascular tissue, (3) tissue breakdown, and (4) chronic non-healing wound.

Original languageEnglish
Pages (from-to)283-288
Number of pages6
JournalJournal of Oral and Maxillofacial Surgery
Volume41
Issue number5
DOIs
StatePublished - Jan 1 1983
Externally publishedYes

Fingerprint

Osteoradionecrosis
Wounds and Injuries
Radiation
Jaw
Pathology
Infection

ASJC Scopus subject areas

  • Surgery
  • Dentistry(all)

Cite this

Osteoradionecrosis : A new concept of its pathophysiology. / Marx, Robert.

In: Journal of Oral and Maxillofacial Surgery, Vol. 41, No. 5, 01.01.1983, p. 283-288.

Research output: Contribution to journalArticle

@article{007d655ead26475ea7aa6685178605fd,
title = "Osteoradionecrosis: A new concept of its pathophysiology",
abstract = "The classic sequence in the pathogenesis of osteoradionecrosis of the jaws has been accepted as radiation, trauma, and infection. This paper challenges this sequence and offers a new one more accurately describing the biochemical and cellular pathology. The clinical data are based on 26 consecutive cases of osteoradionecrosis from which 12 en bloc resection specimens were cultured and stained for microorganisms. Review of the histories and treatments, as well as the microbial assays, indicates that microorganisms play only a contaminant role in osteoradionecrosis and that trauma is only one mechanism of tissue breakdown leading to the condition. The sequence suggested by this study is as follows: (1) radiation, (2) hypoxic-hypocellular-hypovascular tissue, (3) tissue breakdown, and (4) chronic non-healing wound.",
author = "Robert Marx",
year = "1983",
month = "1",
day = "1",
doi = "10.1016/0278-2391(83)90294-X",
language = "English",
volume = "41",
pages = "283--288",
journal = "Journal of Oral and Maxillofacial Surgery",
issn = "0278-2391",
publisher = "W.B. Saunders Ltd",
number = "5",

}

TY - JOUR

T1 - Osteoradionecrosis

T2 - A new concept of its pathophysiology

AU - Marx, Robert

PY - 1983/1/1

Y1 - 1983/1/1

N2 - The classic sequence in the pathogenesis of osteoradionecrosis of the jaws has been accepted as radiation, trauma, and infection. This paper challenges this sequence and offers a new one more accurately describing the biochemical and cellular pathology. The clinical data are based on 26 consecutive cases of osteoradionecrosis from which 12 en bloc resection specimens were cultured and stained for microorganisms. Review of the histories and treatments, as well as the microbial assays, indicates that microorganisms play only a contaminant role in osteoradionecrosis and that trauma is only one mechanism of tissue breakdown leading to the condition. The sequence suggested by this study is as follows: (1) radiation, (2) hypoxic-hypocellular-hypovascular tissue, (3) tissue breakdown, and (4) chronic non-healing wound.

AB - The classic sequence in the pathogenesis of osteoradionecrosis of the jaws has been accepted as radiation, trauma, and infection. This paper challenges this sequence and offers a new one more accurately describing the biochemical and cellular pathology. The clinical data are based on 26 consecutive cases of osteoradionecrosis from which 12 en bloc resection specimens were cultured and stained for microorganisms. Review of the histories and treatments, as well as the microbial assays, indicates that microorganisms play only a contaminant role in osteoradionecrosis and that trauma is only one mechanism of tissue breakdown leading to the condition. The sequence suggested by this study is as follows: (1) radiation, (2) hypoxic-hypocellular-hypovascular tissue, (3) tissue breakdown, and (4) chronic non-healing wound.

UR - http://www.scopus.com/inward/record.url?scp=0020530740&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0020530740&partnerID=8YFLogxK

U2 - 10.1016/0278-2391(83)90294-X

DO - 10.1016/0278-2391(83)90294-X

M3 - Article

C2 - 6572704

AN - SCOPUS:0020530740

VL - 41

SP - 283

EP - 288

JO - Journal of Oral and Maxillofacial Surgery

JF - Journal of Oral and Maxillofacial Surgery

SN - 0278-2391

IS - 5

ER -