Osteoporosis fracture risk assessment

Research output: Contribution to journalArticle

Abstract

Osteoporotic fractures pose a significant burden on society and the healthcare system worldwide. Unless there is a known fragility fracture, the diagnosis of osteoporosis is based on the World Health Organization (WHO) T-score criteria using central dual-energy X-ray absorptiometry (DXA). A large number of patients, however, who suffer from a low-trauma fracture, do not meet the T-score definition of osteoporosis. Conversely, younger individuals with bone mineral density in the osteoporotic range without other risk factors often have low fracture risk, but are commonly prescribed osteoporosis therapies. Bone mineral density is an important measure of fracture risk but has low sensitivity and low positive predictive value for fractures, resulting in the development of fracture risk assessment tools such as FRAX®. FRAX utilises bone mineral density and clinical risk factors to assess 10-year probability of major osteoporosis-related and hip-related fracture risk. FRAX is being used in a growing number of countries worldwide to define cost-effective intervention strategies for primary and secondary fracture prevention.

Original languageEnglish
Pages (from-to)151-156
Number of pages6
JournalEuropean Musculoskeletal Review
Volume7
Issue number3
StatePublished - Oct 3 2012

Fingerprint

Osteoporosis
Bone Density
Osteoporotic Fractures
Photon Absorptiometry
Hip Fractures
Secondary Prevention
Delivery of Health Care
Costs and Cost Analysis
Wounds and Injuries
Therapeutics

Keywords

  • Bone density
  • Fracture
  • Fracture risk
  • FRAX
  • Osteoporosis

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine

Cite this

Osteoporosis fracture risk assessment. / Lagari-Libhaber, Violet; Baim, Sanford.

In: European Musculoskeletal Review, Vol. 7, No. 3, 03.10.2012, p. 151-156.

Research output: Contribution to journalArticle

Lagari-Libhaber, Violet ; Baim, Sanford. / Osteoporosis fracture risk assessment. In: European Musculoskeletal Review. 2012 ; Vol. 7, No. 3. pp. 151-156.
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