Abstract
Osteoporotic fractures pose a significant burden on society and the healthcare system worldwide. Unless there is a known fragility fracture, the diagnosis of osteoporosis is based on the World Health Organization (WHO) T-score criteria using central dual-energy X-ray absorptiometry (DXA). A large number of patients, however, who suffer from a low-trauma fracture, do not meet the T-score definition of osteoporosis. Conversely, younger individuals with bone mineral density in the osteoporotic range without other risk factors often have low fracture risk, but are commonly prescribed osteoporosis therapies. Bone mineral density is an important measure of fracture risk but has low sensitivity and low positive predictive value for fractures, resulting in the development of fracture risk assessment tools such as FRAX®. FRAX utilises bone mineral density and clinical risk factors to assess 10-year probability of major osteoporosis-related and hip-related fracture risk. FRAX is being used in a growing number of countries worldwide to define cost-effective intervention strategies for primary and secondary fracture prevention.
| Original language | English |
|---|---|
| Pages (from-to) | 151-156 |
| Number of pages | 6 |
| Journal | European Musculoskeletal Review |
| Volume | 7 |
| Issue number | 3 |
| State | Published - Oct 3 2012 |
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Keywords
- Bone density
- Fracture
- Fracture risk
- FRAX
- Osteoporosis
ASJC Scopus subject areas
- Orthopedics and Sports Medicine
Cite this
Osteoporosis fracture risk assessment. / Lagari-Libhaber, Violet; Baim, Sanford.
In: European Musculoskeletal Review, Vol. 7, No. 3, 03.10.2012, p. 151-156.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Osteoporosis fracture risk assessment
AU - Lagari-Libhaber, Violet
AU - Baim, Sanford
PY - 2012/10/3
Y1 - 2012/10/3
N2 - Osteoporotic fractures pose a significant burden on society and the healthcare system worldwide. Unless there is a known fragility fracture, the diagnosis of osteoporosis is based on the World Health Organization (WHO) T-score criteria using central dual-energy X-ray absorptiometry (DXA). A large number of patients, however, who suffer from a low-trauma fracture, do not meet the T-score definition of osteoporosis. Conversely, younger individuals with bone mineral density in the osteoporotic range without other risk factors often have low fracture risk, but are commonly prescribed osteoporosis therapies. Bone mineral density is an important measure of fracture risk but has low sensitivity and low positive predictive value for fractures, resulting in the development of fracture risk assessment tools such as FRAX®. FRAX utilises bone mineral density and clinical risk factors to assess 10-year probability of major osteoporosis-related and hip-related fracture risk. FRAX is being used in a growing number of countries worldwide to define cost-effective intervention strategies for primary and secondary fracture prevention.
AB - Osteoporotic fractures pose a significant burden on society and the healthcare system worldwide. Unless there is a known fragility fracture, the diagnosis of osteoporosis is based on the World Health Organization (WHO) T-score criteria using central dual-energy X-ray absorptiometry (DXA). A large number of patients, however, who suffer from a low-trauma fracture, do not meet the T-score definition of osteoporosis. Conversely, younger individuals with bone mineral density in the osteoporotic range without other risk factors often have low fracture risk, but are commonly prescribed osteoporosis therapies. Bone mineral density is an important measure of fracture risk but has low sensitivity and low positive predictive value for fractures, resulting in the development of fracture risk assessment tools such as FRAX®. FRAX utilises bone mineral density and clinical risk factors to assess 10-year probability of major osteoporosis-related and hip-related fracture risk. FRAX is being used in a growing number of countries worldwide to define cost-effective intervention strategies for primary and secondary fracture prevention.
KW - Bone density
KW - Fracture
KW - Fracture risk
KW - FRAX
KW - Osteoporosis
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M3 - Article
AN - SCOPUS:84866781310
VL - 7
SP - 151
EP - 156
JO - European Musculoskeletal Review
JF - European Musculoskeletal Review
SN - 1754-5072
IS - 3
ER -