Osteopontin polymorphisms and disease course in multiple sclerosis

S. Caillier, L. F. Barcellos, S. E. Baranzini, A. Swerdlin, R. R. Lincoln, L. Steinman, Eden R Martin, J. L. Haines, Margaret A Pericak-Vance, S. L. Hauser, J. R. Oksenberg

Research output: Contribution to journalArticle

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Abstract

Osteopontin (OPN), also known as early T-cell activating gene (Eta-l), has been recently shown to be a critical factor in the progression of experimental autoimmune encephalomyelitis, and perhaps multiple sclerosis (MS). Here we investigated whether the 327T/C, 795C/T, 1128A/G or 1284A/C single-nucleotide polymorphisms in the OPN gene were correlated with susceptibility or any of the several clinical end points in a cohort of 821 MS patients. Overall, we observed no evidence of genetic association between the OPN polymorphisms and MS. Although not reaching statistical significance, a modest trend for association with disease course was detected in patients carrying at least one wild-type 1284A allele, suggesting an effect on disease course. Patients with this genotype were less likely to have a mild disease course and were at increased risk for a secondary-progressive clinical type.

Original languageEnglish
Pages (from-to)312-315
Number of pages4
JournalGenes and Immunity
Volume4
Issue number4
DOIs
StatePublished - Jun 1 2003
Externally publishedYes

Fingerprint

Osteopontin
Multiple Sclerosis
Autoimmune Experimental Encephalomyelitis
Genes
Single Nucleotide Polymorphism
Alleles
Genotype
T-Lymphocytes

Keywords

  • Multiple sclerosis
  • Osteopontin
  • Single-nucleotide polymorphisms

ASJC Scopus subject areas

  • Genetics(clinical)
  • Immunology
  • Genetics

Cite this

Caillier, S., Barcellos, L. F., Baranzini, S. E., Swerdlin, A., Lincoln, R. R., Steinman, L., ... Oksenberg, J. R. (2003). Osteopontin polymorphisms and disease course in multiple sclerosis. Genes and Immunity, 4(4), 312-315. https://doi.org/10.1038/sj.gene.6363952

Osteopontin polymorphisms and disease course in multiple sclerosis. / Caillier, S.; Barcellos, L. F.; Baranzini, S. E.; Swerdlin, A.; Lincoln, R. R.; Steinman, L.; Martin, Eden R; Haines, J. L.; Pericak-Vance, Margaret A; Hauser, S. L.; Oksenberg, J. R.

In: Genes and Immunity, Vol. 4, No. 4, 01.06.2003, p. 312-315.

Research output: Contribution to journalArticle

Caillier, S, Barcellos, LF, Baranzini, SE, Swerdlin, A, Lincoln, RR, Steinman, L, Martin, ER, Haines, JL, Pericak-Vance, MA, Hauser, SL & Oksenberg, JR 2003, 'Osteopontin polymorphisms and disease course in multiple sclerosis', Genes and Immunity, vol. 4, no. 4, pp. 312-315. https://doi.org/10.1038/sj.gene.6363952
Caillier S, Barcellos LF, Baranzini SE, Swerdlin A, Lincoln RR, Steinman L et al. Osteopontin polymorphisms and disease course in multiple sclerosis. Genes and Immunity. 2003 Jun 1;4(4):312-315. https://doi.org/10.1038/sj.gene.6363952
Caillier, S. ; Barcellos, L. F. ; Baranzini, S. E. ; Swerdlin, A. ; Lincoln, R. R. ; Steinman, L. ; Martin, Eden R ; Haines, J. L. ; Pericak-Vance, Margaret A ; Hauser, S. L. ; Oksenberg, J. R. / Osteopontin polymorphisms and disease course in multiple sclerosis. In: Genes and Immunity. 2003 ; Vol. 4, No. 4. pp. 312-315.
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