Osteopontin polymorphisms and disease course in multiple sclerosis

S. Caillier, L. F. Barcellos, S. E. Baranzini, A. Swerdlin, R. R. Lincoln, L. Steinman, E. Martin, J. L. Haines, M. Pericak-Vance, S. L. Hauser, J. R. Oksenberg

Research output: Contribution to journalArticlepeer-review

52 Scopus citations


Osteopontin (OPN), also known as early T-cell activating gene (Eta-l), has been recently shown to be a critical factor in the progression of experimental autoimmune encephalomyelitis, and perhaps multiple sclerosis (MS). Here we investigated whether the 327T/C, 795C/T, 1128A/G or 1284A/C single-nucleotide polymorphisms in the OPN gene were correlated with susceptibility or any of the several clinical end points in a cohort of 821 MS patients. Overall, we observed no evidence of genetic association between the OPN polymorphisms and MS. Although not reaching statistical significance, a modest trend for association with disease course was detected in patients carrying at least one wild-type 1284A allele, suggesting an effect on disease course. Patients with this genotype were less likely to have a mild disease course and were at increased risk for a secondary-progressive clinical type.

Original languageEnglish (US)
Pages (from-to)312-315
Number of pages4
JournalGenes and Immunity
Issue number4
StatePublished - Jun 2003
Externally publishedYes


  • Multiple sclerosis
  • Osteopontin
  • Single-nucleotide polymorphisms

ASJC Scopus subject areas

  • Genetics(clinical)
  • Immunology
  • Genetics


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