Osteopontin polymorphisms and disease course in multiple sclerosis

S. Caillier, L. F. Barcellos, S. E. Baranzini, A. Swerdlin, R. R. Lincoln, L. Steinman, E. Martin, J. L. Haines, M. Pericak-Vance, S. L. Hauser, J. R. Oksenberg

Research output: Contribution to journalArticle

52 Scopus citations

Abstract

Osteopontin (OPN), also known as early T-cell activating gene (Eta-l), has been recently shown to be a critical factor in the progression of experimental autoimmune encephalomyelitis, and perhaps multiple sclerosis (MS). Here we investigated whether the 327T/C, 795C/T, 1128A/G or 1284A/C single-nucleotide polymorphisms in the OPN gene were correlated with susceptibility or any of the several clinical end points in a cohort of 821 MS patients. Overall, we observed no evidence of genetic association between the OPN polymorphisms and MS. Although not reaching statistical significance, a modest trend for association with disease course was detected in patients carrying at least one wild-type 1284A allele, suggesting an effect on disease course. Patients with this genotype were less likely to have a mild disease course and were at increased risk for a secondary-progressive clinical type.

Original languageEnglish (US)
Pages (from-to)312-315
Number of pages4
JournalGenes and Immunity
Volume4
Issue number4
DOIs
StatePublished - Jun 1 2003
Externally publishedYes

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Keywords

  • Multiple sclerosis
  • Osteopontin
  • Single-nucleotide polymorphisms

ASJC Scopus subject areas

  • Genetics(clinical)
  • Immunology
  • Genetics

Cite this

Caillier, S., Barcellos, L. F., Baranzini, S. E., Swerdlin, A., Lincoln, R. R., Steinman, L., Martin, E., Haines, J. L., Pericak-Vance, M., Hauser, S. L., & Oksenberg, J. R. (2003). Osteopontin polymorphisms and disease course in multiple sclerosis. Genes and Immunity, 4(4), 312-315. https://doi.org/10.1038/sj.gene.6363952