Osteomyelitis of the base of the skull

J. R. Chandler, L. Grobman, Robert Quencer, Aldo N Serafini

Research output: Contribution to journalArticle

73 Citations (Scopus)

Abstract

Infection in the marrow of the temporal, occipital, and sphenoid bones is an uncommon, but increasing occurrence. It is usually secondary to infections beginning in the external auditory canal and is caused almost uniformly by the gram negative Pseudomonas aeruginosa bacteria. Technetium and gallium scintigraphy help in the early detection of such infections while CT scans demonstrate dissolution of bone in well-developed cases. Headache is the predominant symptom. Dysphagia, hoarseness, and aspiration herald the inevitable march of cranial nerves. We have diagnosed and treated 17 cases of osteomyelitis of the skull base. Although the total mortality rate is 53%, it is now a curable disease. Six of our last 8 patients remain alive, although 1 is still under treatment. Treatment is medical and requires the long-term concomitant intravenous administration of an aminoglycoside and a broad spectrum semisynthetic penicillin effective against the causative organism.

Original languageEnglish
Pages (from-to)245-251
Number of pages7
JournalLaryngoscope
Volume96
Issue number3
StatePublished - Jan 1 1986

Fingerprint

Skull Base
Osteomyelitis
Sphenoid Bone
Occipital Bone
Hoarseness
Ear Canal
Gallium
Cranial Nerves
Temporal Bone
Technetium
Aminoglycosides
Deglutition Disorders
Infection
Coinfection
Radionuclide Imaging
Penicillins
Intravenous Administration
Pseudomonas aeruginosa
Headache
Bone Marrow

ASJC Scopus subject areas

  • Otorhinolaryngology

Cite this

Chandler, J. R., Grobman, L., Quencer, R., & Serafini, A. N. (1986). Osteomyelitis of the base of the skull. Laryngoscope, 96(3), 245-251.

Osteomyelitis of the base of the skull. / Chandler, J. R.; Grobman, L.; Quencer, Robert; Serafini, Aldo N.

In: Laryngoscope, Vol. 96, No. 3, 01.01.1986, p. 245-251.

Research output: Contribution to journalArticle

Chandler, JR, Grobman, L, Quencer, R & Serafini, AN 1986, 'Osteomyelitis of the base of the skull', Laryngoscope, vol. 96, no. 3, pp. 245-251.
Chandler JR, Grobman L, Quencer R, Serafini AN. Osteomyelitis of the base of the skull. Laryngoscope. 1986 Jan 1;96(3):245-251.
Chandler, J. R. ; Grobman, L. ; Quencer, Robert ; Serafini, Aldo N. / Osteomyelitis of the base of the skull. In: Laryngoscope. 1986 ; Vol. 96, No. 3. pp. 245-251.
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