TY - JOUR
T1 - Osteogenic Potential of Leukemic Marrow
AU - Ratzan, R. Judith
AU - Tavassoli, Mehdi
AU - Crosby, William H.
N1 - Funding Information:
These studies were aided with funds from U.S. Public Health Service Grant No. AM 12444- from the National Institute of Arthritis and Metabolic Diseases and Atomic Energy Commission Contract number AT (11-1) 3375. 2
Funding Information:
Trainee in Hematology under U.S. Public Health Service Graduate Training Grant No. AM 5210-from the National Institute of Arthritis and Metabolic Diseases. Present address: University of Miami, FL. 3
Copyright:
Copyright 2016 Elsevier B.V., All rights reserved.
PY - 1973/6
Y1 - 1973/6
N2 - Intravenous injection of 20 × 106 Shay chloroleukemia cells into 50 g rats induces acute granulocytic leukemia with infiltration of marrow and blood. Most animals die within 12 days. Marrow tissue obtained from these animals and implanted into subcutaneous tissue of normal recipients produces bone which is later rejected. We, therefore, conclude that the leukemic marrow tissue, despite the reported injury to its potentially osteogenic cellular reticulum, retains its osteogenic potential. This observation may be of significance in explaining why the course of leukemia, unlike myeloma and other infiltrative diseases of the marrow, is not associated with bone destruction.
AB - Intravenous injection of 20 × 106 Shay chloroleukemia cells into 50 g rats induces acute granulocytic leukemia with infiltration of marrow and blood. Most animals die within 12 days. Marrow tissue obtained from these animals and implanted into subcutaneous tissue of normal recipients produces bone which is later rejected. We, therefore, conclude that the leukemic marrow tissue, despite the reported injury to its potentially osteogenic cellular reticulum, retains its osteogenic potential. This observation may be of significance in explaining why the course of leukemia, unlike myeloma and other infiltrative diseases of the marrow, is not associated with bone destruction.
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U2 - 10.3181/00379727-143-37328
DO - 10.3181/00379727-143-37328
M3 - Article
C2 - 4575414
AN - SCOPUS:0015888659
VL - 143
SP - 391
EP - 394
JO - Experimental Biology and Medicine
JF - Experimental Biology and Medicine
SN - 0037-9727
IS - 2
ER -