Osteogenic Potential of Leukemic Marrow

R. Judith Ratzan; Mehdi Tavassoli; William H. Crosby

doi:10.3181/00379727-143-37328

Osteogenic Potential of Leukemic Marrow

R. Judith Ratzan, Mehdi Tavassoli, William H. Crosby

Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

Intravenous injection of 20 × 10⁶ Shay chloroleukemia cells into 50 g rats induces acute granulocytic leukemia with infiltration of marrow and blood. Most animals die within 12 days. Marrow tissue obtained from these animals and implanted into subcutaneous tissue of normal recipients produces bone which is later rejected. We, therefore, conclude that the leukemic marrow tissue, despite the reported injury to its potentially osteogenic cellular reticulum, retains its osteogenic potential. This observation may be of significance in explaining why the course of leukemia, unlike myeloma and other infiltrative diseases of the marrow, is not associated with bone destruction.

Original language	English (US)
Pages (from-to)	391-394
Number of pages	4
Journal	Proceedings of the Society for Experimental Biology and Medicine
Volume	143
Issue number	2
DOIs	https://doi.org/10.3181/00379727-143-37328
State	Published - Jun 1973

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

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AB - Intravenous injection of 20 × 106 Shay chloroleukemia cells into 50 g rats induces acute granulocytic leukemia with infiltration of marrow and blood. Most animals die within 12 days. Marrow tissue obtained from these animals and implanted into subcutaneous tissue of normal recipients produces bone which is later rejected. We, therefore, conclude that the leukemic marrow tissue, despite the reported injury to its potentially osteogenic cellular reticulum, retains its osteogenic potential. This observation may be of significance in explaining why the course of leukemia, unlike myeloma and other infiltrative diseases of the marrow, is not associated with bone destruction.

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