Osteogenesis imperfecta and hyperplastic callus formation in a family

A report of three cases and a review of the literature

Norman Ramírez, Fernando Vilella-Hernandez, Mirylsa Colón, John M. Flynn

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Osteogenesis imperfecta is one of the most common groups of inherited disorders of connective tissue. Hyperplastic callus formation in patients with osteogenesis imperfecta after fracture or surgery is a rare occurrence that has often been misdiagnosed as osteosarcoma. Previous series reported that hyperplastic callus formation is more often present in osteogenesis imperfecta male patients, with white sclerae, and a negative family history of the disorder. This is the first time that this complication has been presented in three female siblings, with a positive family history of osteogenesis imperfecta type IV. An association between osteogenesis imperfecta type IV and hyperplastic callus formation is unclear. This association might, however, be a separate, specific subtype of osteogenesis imperfecta, with an unknown inheritance pattern.

Original languageEnglish
Pages (from-to)88-96
Number of pages9
JournalJournal of Pediatric Orthopaedics Part B
Volume12
Issue number2
DOIs
StatePublished - Mar 1 2003
Externally publishedYes

Fingerprint

Osteogenesis Imperfecta
Bony Callus
Inheritance Patterns
Sclera
Osteosarcoma
Diagnostic Errors
Connective Tissue
Siblings
Type 4 Osteogenesis imperfecta

Keywords

  • Hyperplastic callus
  • Osteogenesis imperfecta

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Surgery
  • Orthopedics and Sports Medicine

Cite this

Osteogenesis imperfecta and hyperplastic callus formation in a family : A report of three cases and a review of the literature. / Ramírez, Norman; Vilella-Hernandez, Fernando; Colón, Mirylsa; Flynn, John M.

In: Journal of Pediatric Orthopaedics Part B, Vol. 12, No. 2, 01.03.2003, p. 88-96.

Research output: Contribution to journalArticle

Ramírez, Norman ; Vilella-Hernandez, Fernando ; Colón, Mirylsa ; Flynn, John M. / Osteogenesis imperfecta and hyperplastic callus formation in a family : A report of three cases and a review of the literature. In: Journal of Pediatric Orthopaedics Part B. 2003 ; Vol. 12, No. 2. pp. 88-96.
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