Orthotopic liver transplantation for primary sclerosing cholangitis: A 12-year single center experience

John A. Goss, Christopher R. Shackleton, Douglas G. Farmer, Walid S. Arnaout, Philip Seu, Jay S. Markowitz, Paul Martin, Risë J. Stribling, Leonard I. Goldstein, Ronald W. Busuttil

Research output: Contribution to journalArticle

270 Citations (Scopus)

Abstract

Objective: The purpose of this study was to analyze a single center's 12-year experience with 127 orthotopic liver transplantations (OLT) for primary sclerosing cholangitis (PSC). Summary Background Data: Primary sclerosing cholangitis is a chronic cholestatic liver disease of unknown origin that occurs most commonly in young men and is associated frequently (70%-80%) with inflammatory bowel disease (IBD). Patients with PSC also are at risk for the development of cholangiocarcinoma (CCA) and those with IBD for colon carcinoma. Although the course of PSC is variable, it frequently is progressive, leading to cirrhosis and requirement for OLT. Methods: The medical records of 127 consecutive patients undergoing OLT for PSC from July 1, 1984, to May 30, 1996, were reviewed. Actuarial patient and graft survival was determined at 1, 2, and 5 years. The incidence and outcome of patients with CCA, recurrent sclerosing cholangitis, and post-transplant colon carcinoma was determined. Results were analyzed by way of stepwise Cox regression to determine the statistical strength of independent associations between pretransplant covariates and patient survival. The median follow-up period was 3.01 years. Incidental cholangiocarcinoma (ICCA) was defined as a tumor <1 cm in size that was discovered at the time of pathologic sectioning of the explanted liver. Results: Ninety-two patients (72%) had associated IBD. Seventy-nine (62%) had undergone previous biliary tract surgery. One hundred seven patients (84%) received a single graft, whereas 20 patients (16%) required 22 retransplants. Patients received either cyclosporine- (n = 76) or tacrolimus- (n = 51) based immunosuppression. The 1-, 2-, and 5-year actuarial patient survivals were 90%, 86%, and 85%, respectively, whereas graft survival was 82%, 77%, and 72%, respectively. The presence of previous biliary surgery had no effect on patient survival. Ten patients (8%) had ICCA and their survival was not significantly different from patients without ICCA (100%, 83%, and 83% at 1, 2, and 5 years, respectively). Four patients were known to have CCA at the time of OLT, all recurred within 6 months, and had a significantly worse outcome (p < 0.0001). Recurrent sclerosing cholangitis developed in 11 patients (8.6%). The patient and graft survival in this group was not different from those in whom recurrence did not develop (patient: 100%, 90%, and 90%; graft: 80%, 70%, and 52%). Thirty patients (23%) underwent colectomy after liver transplantation for dysplasia-carcinoma or symptomatic colitis. Of the nine covariates entered into the Cox multivariate regression analysis, only common bile duct frozen section biopsy specimen showing CCA was predictive of a survival disadvantage. Conclusions: Liver transplantation provides excellent patient and graft survival rates for patients affected with PSC independent of pretransplant biliary tract surgery. Incidental cholangiocarcinoma does not affect patient survival significantly. However, known CCA or common duct frozen section biopsy specimen or both showing CCA are associated with poor recipient survival, and OLT should be proscribed in these cases. Recurrent PSC occurs in approximately 9% of cases but does not affect patient survival. Post- transplant colectomy does not affect patient survival adversely.

Original languageEnglish
Pages (from-to)472-483
Number of pages12
JournalAnnals of Surgery
Volume225
Issue number5
DOIs
StatePublished - Jan 1 1997
Externally publishedYes

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Sclerosing Cholangitis
compound A 12
Liver Transplantation
Cholangiocarcinoma
Survival
Graft Survival
Inflammatory Bowel Diseases
Transplants
Colectomy
Frozen Sections
Biliary Tract
Carcinoma
Colon

ASJC Scopus subject areas

  • Surgery

Cite this

Goss, J. A., Shackleton, C. R., Farmer, D. G., Arnaout, W. S., Seu, P., Markowitz, J. S., ... Busuttil, R. W. (1997). Orthotopic liver transplantation for primary sclerosing cholangitis: A 12-year single center experience. Annals of Surgery, 225(5), 472-483. https://doi.org/10.1097/00000658-199705000-00004

Orthotopic liver transplantation for primary sclerosing cholangitis : A 12-year single center experience. / Goss, John A.; Shackleton, Christopher R.; Farmer, Douglas G.; Arnaout, Walid S.; Seu, Philip; Markowitz, Jay S.; Martin, Paul; Stribling, Risë J.; Goldstein, Leonard I.; Busuttil, Ronald W.

In: Annals of Surgery, Vol. 225, No. 5, 01.01.1997, p. 472-483.

Research output: Contribution to journalArticle

Goss, JA, Shackleton, CR, Farmer, DG, Arnaout, WS, Seu, P, Markowitz, JS, Martin, P, Stribling, RJ, Goldstein, LI & Busuttil, RW 1997, 'Orthotopic liver transplantation for primary sclerosing cholangitis: A 12-year single center experience', Annals of Surgery, vol. 225, no. 5, pp. 472-483. https://doi.org/10.1097/00000658-199705000-00004
Goss, John A. ; Shackleton, Christopher R. ; Farmer, Douglas G. ; Arnaout, Walid S. ; Seu, Philip ; Markowitz, Jay S. ; Martin, Paul ; Stribling, Risë J. ; Goldstein, Leonard I. ; Busuttil, Ronald W. / Orthotopic liver transplantation for primary sclerosing cholangitis : A 12-year single center experience. In: Annals of Surgery. 1997 ; Vol. 225, No. 5. pp. 472-483.
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abstract = "Objective: The purpose of this study was to analyze a single center's 12-year experience with 127 orthotopic liver transplantations (OLT) for primary sclerosing cholangitis (PSC). Summary Background Data: Primary sclerosing cholangitis is a chronic cholestatic liver disease of unknown origin that occurs most commonly in young men and is associated frequently (70{\%}-80{\%}) with inflammatory bowel disease (IBD). Patients with PSC also are at risk for the development of cholangiocarcinoma (CCA) and those with IBD for colon carcinoma. Although the course of PSC is variable, it frequently is progressive, leading to cirrhosis and requirement for OLT. Methods: The medical records of 127 consecutive patients undergoing OLT for PSC from July 1, 1984, to May 30, 1996, were reviewed. Actuarial patient and graft survival was determined at 1, 2, and 5 years. The incidence and outcome of patients with CCA, recurrent sclerosing cholangitis, and post-transplant colon carcinoma was determined. Results were analyzed by way of stepwise Cox regression to determine the statistical strength of independent associations between pretransplant covariates and patient survival. The median follow-up period was 3.01 years. Incidental cholangiocarcinoma (ICCA) was defined as a tumor <1 cm in size that was discovered at the time of pathologic sectioning of the explanted liver. Results: Ninety-two patients (72{\%}) had associated IBD. Seventy-nine (62{\%}) had undergone previous biliary tract surgery. One hundred seven patients (84{\%}) received a single graft, whereas 20 patients (16{\%}) required 22 retransplants. Patients received either cyclosporine- (n = 76) or tacrolimus- (n = 51) based immunosuppression. The 1-, 2-, and 5-year actuarial patient survivals were 90{\%}, 86{\%}, and 85{\%}, respectively, whereas graft survival was 82{\%}, 77{\%}, and 72{\%}, respectively. The presence of previous biliary surgery had no effect on patient survival. Ten patients (8{\%}) had ICCA and their survival was not significantly different from patients without ICCA (100{\%}, 83{\%}, and 83{\%} at 1, 2, and 5 years, respectively). Four patients were known to have CCA at the time of OLT, all recurred within 6 months, and had a significantly worse outcome (p < 0.0001). Recurrent sclerosing cholangitis developed in 11 patients (8.6{\%}). The patient and graft survival in this group was not different from those in whom recurrence did not develop (patient: 100{\%}, 90{\%}, and 90{\%}; graft: 80{\%}, 70{\%}, and 52{\%}). Thirty patients (23{\%}) underwent colectomy after liver transplantation for dysplasia-carcinoma or symptomatic colitis. Of the nine covariates entered into the Cox multivariate regression analysis, only common bile duct frozen section biopsy specimen showing CCA was predictive of a survival disadvantage. Conclusions: Liver transplantation provides excellent patient and graft survival rates for patients affected with PSC independent of pretransplant biliary tract surgery. Incidental cholangiocarcinoma does not affect patient survival significantly. However, known CCA or common duct frozen section biopsy specimen or both showing CCA are associated with poor recipient survival, and OLT should be proscribed in these cases. Recurrent PSC occurs in approximately 9{\%} of cases but does not affect patient survival. Post- transplant colectomy does not affect patient survival adversely.",
author = "Goss, {John A.} and Shackleton, {Christopher R.} and Farmer, {Douglas G.} and Arnaout, {Walid S.} and Philip Seu and Markowitz, {Jay S.} and Paul Martin and Stribling, {Ris{\"e} J.} and Goldstein, {Leonard I.} and Busuttil, {Ronald W.}",
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TY - JOUR

T1 - Orthotopic liver transplantation for primary sclerosing cholangitis

T2 - A 12-year single center experience

AU - Goss, John A.

AU - Shackleton, Christopher R.

AU - Farmer, Douglas G.

AU - Arnaout, Walid S.

AU - Seu, Philip

AU - Markowitz, Jay S.

AU - Martin, Paul

AU - Stribling, Risë J.

AU - Goldstein, Leonard I.

AU - Busuttil, Ronald W.

PY - 1997/1/1

Y1 - 1997/1/1

N2 - Objective: The purpose of this study was to analyze a single center's 12-year experience with 127 orthotopic liver transplantations (OLT) for primary sclerosing cholangitis (PSC). Summary Background Data: Primary sclerosing cholangitis is a chronic cholestatic liver disease of unknown origin that occurs most commonly in young men and is associated frequently (70%-80%) with inflammatory bowel disease (IBD). Patients with PSC also are at risk for the development of cholangiocarcinoma (CCA) and those with IBD for colon carcinoma. Although the course of PSC is variable, it frequently is progressive, leading to cirrhosis and requirement for OLT. Methods: The medical records of 127 consecutive patients undergoing OLT for PSC from July 1, 1984, to May 30, 1996, were reviewed. Actuarial patient and graft survival was determined at 1, 2, and 5 years. The incidence and outcome of patients with CCA, recurrent sclerosing cholangitis, and post-transplant colon carcinoma was determined. Results were analyzed by way of stepwise Cox regression to determine the statistical strength of independent associations between pretransplant covariates and patient survival. The median follow-up period was 3.01 years. Incidental cholangiocarcinoma (ICCA) was defined as a tumor <1 cm in size that was discovered at the time of pathologic sectioning of the explanted liver. Results: Ninety-two patients (72%) had associated IBD. Seventy-nine (62%) had undergone previous biliary tract surgery. One hundred seven patients (84%) received a single graft, whereas 20 patients (16%) required 22 retransplants. Patients received either cyclosporine- (n = 76) or tacrolimus- (n = 51) based immunosuppression. The 1-, 2-, and 5-year actuarial patient survivals were 90%, 86%, and 85%, respectively, whereas graft survival was 82%, 77%, and 72%, respectively. The presence of previous biliary surgery had no effect on patient survival. Ten patients (8%) had ICCA and their survival was not significantly different from patients without ICCA (100%, 83%, and 83% at 1, 2, and 5 years, respectively). Four patients were known to have CCA at the time of OLT, all recurred within 6 months, and had a significantly worse outcome (p < 0.0001). Recurrent sclerosing cholangitis developed in 11 patients (8.6%). The patient and graft survival in this group was not different from those in whom recurrence did not develop (patient: 100%, 90%, and 90%; graft: 80%, 70%, and 52%). Thirty patients (23%) underwent colectomy after liver transplantation for dysplasia-carcinoma or symptomatic colitis. Of the nine covariates entered into the Cox multivariate regression analysis, only common bile duct frozen section biopsy specimen showing CCA was predictive of a survival disadvantage. Conclusions: Liver transplantation provides excellent patient and graft survival rates for patients affected with PSC independent of pretransplant biliary tract surgery. Incidental cholangiocarcinoma does not affect patient survival significantly. However, known CCA or common duct frozen section biopsy specimen or both showing CCA are associated with poor recipient survival, and OLT should be proscribed in these cases. Recurrent PSC occurs in approximately 9% of cases but does not affect patient survival. Post- transplant colectomy does not affect patient survival adversely.

AB - Objective: The purpose of this study was to analyze a single center's 12-year experience with 127 orthotopic liver transplantations (OLT) for primary sclerosing cholangitis (PSC). Summary Background Data: Primary sclerosing cholangitis is a chronic cholestatic liver disease of unknown origin that occurs most commonly in young men and is associated frequently (70%-80%) with inflammatory bowel disease (IBD). Patients with PSC also are at risk for the development of cholangiocarcinoma (CCA) and those with IBD for colon carcinoma. Although the course of PSC is variable, it frequently is progressive, leading to cirrhosis and requirement for OLT. Methods: The medical records of 127 consecutive patients undergoing OLT for PSC from July 1, 1984, to May 30, 1996, were reviewed. Actuarial patient and graft survival was determined at 1, 2, and 5 years. The incidence and outcome of patients with CCA, recurrent sclerosing cholangitis, and post-transplant colon carcinoma was determined. Results were analyzed by way of stepwise Cox regression to determine the statistical strength of independent associations between pretransplant covariates and patient survival. The median follow-up period was 3.01 years. Incidental cholangiocarcinoma (ICCA) was defined as a tumor <1 cm in size that was discovered at the time of pathologic sectioning of the explanted liver. Results: Ninety-two patients (72%) had associated IBD. Seventy-nine (62%) had undergone previous biliary tract surgery. One hundred seven patients (84%) received a single graft, whereas 20 patients (16%) required 22 retransplants. Patients received either cyclosporine- (n = 76) or tacrolimus- (n = 51) based immunosuppression. The 1-, 2-, and 5-year actuarial patient survivals were 90%, 86%, and 85%, respectively, whereas graft survival was 82%, 77%, and 72%, respectively. The presence of previous biliary surgery had no effect on patient survival. Ten patients (8%) had ICCA and their survival was not significantly different from patients without ICCA (100%, 83%, and 83% at 1, 2, and 5 years, respectively). Four patients were known to have CCA at the time of OLT, all recurred within 6 months, and had a significantly worse outcome (p < 0.0001). Recurrent sclerosing cholangitis developed in 11 patients (8.6%). The patient and graft survival in this group was not different from those in whom recurrence did not develop (patient: 100%, 90%, and 90%; graft: 80%, 70%, and 52%). Thirty patients (23%) underwent colectomy after liver transplantation for dysplasia-carcinoma or symptomatic colitis. Of the nine covariates entered into the Cox multivariate regression analysis, only common bile duct frozen section biopsy specimen showing CCA was predictive of a survival disadvantage. Conclusions: Liver transplantation provides excellent patient and graft survival rates for patients affected with PSC independent of pretransplant biliary tract surgery. Incidental cholangiocarcinoma does not affect patient survival significantly. However, known CCA or common duct frozen section biopsy specimen or both showing CCA are associated with poor recipient survival, and OLT should be proscribed in these cases. Recurrent PSC occurs in approximately 9% of cases but does not affect patient survival. Post- transplant colectomy does not affect patient survival adversely.

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