Orthodeoxia platypnea syndrome in a patient with lipomatous hypertrophy of the interatrial septum due to long-term steroid use

Syed S I Bokhari, Howard J. Willens, Maureen Lowery, Adam Wanner, Eduardo De Marchena

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

We describe an unusual case of orthodeoxia platypnea syndrome exacerbated by right ventricular inflow obstruction due to iatrogenic steroid-induced adipose deposition in cardiac tissues. A 68-year-old man on long-term prednisone therapy for eosinophilic pneumonia presented with progressive dyspnea worsened by bending forward. By using pulse oximetry, he was noted to have positional hypoxemia. Transthoracic echocar diogram demonstrated normal right-sided pressures but severe right to left shunting through a patent fora men ovale. Transesophageal echocardiogram showed a large patent foramen ovale, severe lipomatous hypertrophy of the interatrial septum, and massive adipose deposition in the pericardium causing compression of the right ventricular inflow tract. The patient under went percutaneous closure of the patent foramen ovale, which resulted in the resolution of symptoms and hypoxemia. This case is unique because long-term steroid use resulted in reverse Lutembacher physiology and clinical orthodeoxia platypnea syndrome by inducing lipomatous hypertrophy of the interatrial septum and compression of the right atrium.

Original languageEnglish
Pages (from-to)443-445
Number of pages3
JournalChest
Volume139
Issue number2
DOIs
StatePublished - Feb 1 2011

Fingerprint

Patent Foramen Ovale
Hypertrophy
Steroids
Pulmonary Eosinophilia
Oximetry
Pericardium
Prednisone
Heart Atria
Dyspnea
Pressure
Hypoxia
Therapeutics

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Critical Care and Intensive Care Medicine
  • Cardiology and Cardiovascular Medicine

Cite this

Orthodeoxia platypnea syndrome in a patient with lipomatous hypertrophy of the interatrial septum due to long-term steroid use. / Bokhari, Syed S I; Willens, Howard J.; Lowery, Maureen; Wanner, Adam; De Marchena, Eduardo.

In: Chest, Vol. 139, No. 2, 01.02.2011, p. 443-445.

Research output: Contribution to journalArticle

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