Origins and evolutionary diversification of the nuclear receptor superfamily

G. I. Owen, Arthur Z Zelent

Research output: Contribution to journalArticle

86 Citations (Scopus)

Abstract

Nuclear receptors (NRs), which include those for steroid and thyroid hormones as well as retinoids, are encoded by a large gene superfamily that has evolved to regulate nearly every facet of metazoan life, from development to basic metabolism. This article reviews the conservation in structure and function of distinct receptors across different species and attempts to draw conclusions as to the evolution of this gene superfamily. Although sequences related to NRs can be found in plants and yeast, gene sequence analyses suggest that the NR ancestor(s) first appeared in the early metazoans and subsequently diversified into the six receptor sub-families, which were already recognisable at the time of the Arthropoda-Chordata split over 70 million years ago. At the time when a primitive NR energed, the basic components of the transcription regulatory machinery, which are conserved from yeast to vertebrates, were already in place and the ancestral NR must have evolved with the ability to communicate with them. The first such NRs likely acted as monomers and in a ligand-independent fashion. As members of the NR superfamily acquired the ability of hetero- and homodimerise, and to bind and be regulated by ligands, the functional complexity of the NR superfamily increased. This exponentially increasing complexity subsequently provided a potential driving force for evolution of higher organisms by supplying a sophisticated regulatory gene network that could control complex physiological processes during development and in adult organisms.

Original languageEnglish (US)
Pages (from-to)809-827
Number of pages19
JournalCellular and Molecular Life Sciences
Volume57
Issue number5
DOIs
StatePublished - 2000
Externally publishedYes

Fingerprint

Cytoplasmic and Nuclear Receptors
Genes
Yeast
Yeasts
Steroid hormones
Chordata
Physiological Phenomena
Ligands
Plant Genes
Arthropods
Gene Regulatory Networks
Retinoids
Transcription
Thyroid Hormones
Metabolism
Machinery
Sequence Analysis
Vertebrates
Conservation
Monomers

Keywords

  • Arthopod
  • Chromosome
  • Development
  • Genome duplication
  • HOX genes
  • Metazoa
  • Nematode
  • Phylogenetic tree
  • Retinoic acid
  • Steroid receptor

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Cell Biology

Cite this

Origins and evolutionary diversification of the nuclear receptor superfamily. / Owen, G. I.; Zelent, Arthur Z.

In: Cellular and Molecular Life Sciences, Vol. 57, No. 5, 2000, p. 809-827.

Research output: Contribution to journalArticle

Owen, G. I. ; Zelent, Arthur Z. / Origins and evolutionary diversification of the nuclear receptor superfamily. In: Cellular and Molecular Life Sciences. 2000 ; Vol. 57, No. 5. pp. 809-827.
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