Abstract
Using two-dimensional gels, no unique membrane proteins were detected in irreversibly sickled cells. Membranes from irreversibly sickled cells were shown to cross-link much more readily with dithiobis(succinimidyl propionate) than normal erythrocyte membranes. Increased binding of band 4.5 protein and increased intra-chain disulfides were also demonstrated. These changes may correlate to enhanced cellular rigidity.
Original language | English (US) |
---|---|
Pages (from-to) | 1-8 |
Number of pages | 8 |
Journal | BBA - Biomembranes |
Volume | 595 |
Issue number | 1 |
DOIs | |
State | Published - Jan 12 1980 |
Keywords
- (Lymphocyte)
- Capping
- Fluorescent probe
- Ion flux
- Potential change
ASJC Scopus subject areas
- Biochemistry
- Biophysics
- Cell Biology
- Medicine(all)