Organization of the axolemma in amyelinated axons: a cytochemical study in dy/dy dystrophic mice

S. G. Waxman, Walter G Bradley, E. A. Hartwieg

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Previous studies using a variety of techniques have shown that in normal myelinated fibres there are structural differences between the axon membrane at nodes of Ranvier and the internodes beneath the myelin sheath. The present paper reports the results of a cytochemical study on the axon myelination in amyelinated axons in dy/dy dystrophic mice, in which myelination is focally absent owing to a genetic defect. The results indicate that the amyelinated axon membrane, which is known to be capable of sustaining continuous impulse conduction, is structurally different from normal nodal membrane. Comparison of the cytochemical results with physiological and pharmacological data suggests that the amyelinated dystrophic axon membrane may exhibit a lower sodium channel density than normal nodal membrane.

Original languageEnglish
Pages (from-to)301-308
Number of pages8
JournalProceedings of the Royal Society of London - Biological Sciences
Volume201
Issue number1144
StatePublished - Dec 1 1978
Externally publishedYes

Fingerprint

axons
Axons
membrane
Membranes
mice
myelination
Ranvier's Nodes
sodium channels
Sodium Channels
myelin sheath
genetic disorders
Myelin Sheath
internodes
defect
sodium
Pharmacology
Defects
Fibers
methodology

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Agricultural and Biological Sciences (miscellaneous)

Cite this

Organization of the axolemma in amyelinated axons : a cytochemical study in dy/dy dystrophic mice. / Waxman, S. G.; Bradley, Walter G; Hartwieg, E. A.

In: Proceedings of the Royal Society of London - Biological Sciences, Vol. 201, No. 1144, 01.12.1978, p. 301-308.

Research output: Contribution to journalArticle

@article{a40590e723264124a53c68d12a5f34b8,
title = "Organization of the axolemma in amyelinated axons: a cytochemical study in dy/dy dystrophic mice",
abstract = "Previous studies using a variety of techniques have shown that in normal myelinated fibres there are structural differences between the axon membrane at nodes of Ranvier and the internodes beneath the myelin sheath. The present paper reports the results of a cytochemical study on the axon myelination in amyelinated axons in dy/dy dystrophic mice, in which myelination is focally absent owing to a genetic defect. The results indicate that the amyelinated axon membrane, which is known to be capable of sustaining continuous impulse conduction, is structurally different from normal nodal membrane. Comparison of the cytochemical results with physiological and pharmacological data suggests that the amyelinated dystrophic axon membrane may exhibit a lower sodium channel density than normal nodal membrane.",
author = "Waxman, {S. G.} and Bradley, {Walter G} and Hartwieg, {E. A.}",
year = "1978",
month = "12",
day = "1",
language = "English",
volume = "201",
pages = "301--308",
journal = "Proceedings of the Royal Society B: Biological Sciences",
issn = "0800-4622",
publisher = "Royal Society of London",
number = "1144",

}

TY - JOUR

T1 - Organization of the axolemma in amyelinated axons

T2 - a cytochemical study in dy/dy dystrophic mice

AU - Waxman, S. G.

AU - Bradley, Walter G

AU - Hartwieg, E. A.

PY - 1978/12/1

Y1 - 1978/12/1

N2 - Previous studies using a variety of techniques have shown that in normal myelinated fibres there are structural differences between the axon membrane at nodes of Ranvier and the internodes beneath the myelin sheath. The present paper reports the results of a cytochemical study on the axon myelination in amyelinated axons in dy/dy dystrophic mice, in which myelination is focally absent owing to a genetic defect. The results indicate that the amyelinated axon membrane, which is known to be capable of sustaining continuous impulse conduction, is structurally different from normal nodal membrane. Comparison of the cytochemical results with physiological and pharmacological data suggests that the amyelinated dystrophic axon membrane may exhibit a lower sodium channel density than normal nodal membrane.

AB - Previous studies using a variety of techniques have shown that in normal myelinated fibres there are structural differences between the axon membrane at nodes of Ranvier and the internodes beneath the myelin sheath. The present paper reports the results of a cytochemical study on the axon myelination in amyelinated axons in dy/dy dystrophic mice, in which myelination is focally absent owing to a genetic defect. The results indicate that the amyelinated axon membrane, which is known to be capable of sustaining continuous impulse conduction, is structurally different from normal nodal membrane. Comparison of the cytochemical results with physiological and pharmacological data suggests that the amyelinated dystrophic axon membrane may exhibit a lower sodium channel density than normal nodal membrane.

UR - http://www.scopus.com/inward/record.url?scp=0018147347&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0018147347&partnerID=8YFLogxK

M3 - Article

C2 - 27805

AN - SCOPUS:0018147347

VL - 201

SP - 301

EP - 308

JO - Proceedings of the Royal Society B: Biological Sciences

JF - Proceedings of the Royal Society B: Biological Sciences

SN - 0800-4622

IS - 1144

ER -