Organization of four mouse λ light chain immunoglobulin genes

B. Blomberg, A. Traunecker, H. Eisen, S. Tonegawa

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85 Scopus citations


We have cloned four λ light chain constant region (C) genes from mouse embryo DNA. Each carries its own joining (J) segment approximately 1.3 kilobases to its 5' side. The four C genes occur in two clusters, 5' J3C3J1C13' and 5'J2C2J4C43', with C4 being a new Cλ gene. We have also shown that Vλ1 is joined productively with Cλ3 in a λ3-producing myeloma, and it is most likely that Vλ1 and Vλ2 are the only Vλ genes. Based on the analysis of the germ line and rearranged variable region (V) λ genes in myelomas, we argue that the Vλ1 and Vλ2 genes are at the 5' side of the C3C1 and C2C4 clusters, respectively. We propose that the two clusters arose by duplication. We also speculate on the role of J-associated DNA sequences in regulation of expression of the λ subtypes.

Original languageEnglish (US)
Pages (from-to)3765-3769
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Issue number6 I
StatePublished - 1981
Externally publishedYes

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