TY - JOUR
T1 - Orbital Stem Cells
AU - Wester, Sara T.
N1 - Publisher Copyright:
© 2014, Springer Science + Business Media New York.
Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
PY - 2014/9/1
Y1 - 2014/9/1
N2 - Stem cell research in the field of ophthalmology over the past two decades has advanced knowledge and treatment dramatically. Bone marrow-derived stem cells (BM-MSCs) have been widely studied and have many applications in the eye and other organs; since processed lipoaspirate was first identified as a source of adipose tissue derived stem cells (ASCs), further research has blossomed in this exciting new area. Despite the growth in research involving systemic adipose tissue, the orbital adipose tissue, which is unique in its embryology and has an abundant supply of stem cells, has only recently gained attention. The purpose of this chapter is to outline our current knowledge and recent advances in stem cell research and applications in the orbit, particular orbital adipose stem cells. This chapter will review the fundamentals of adipose stem cell research, the role of orbital fat, dysregulation of orbital adipogenesis, new research on orbital fat stem cells (OFSCs), and potential applications in inflammatory disease and reconstructive and esthetic surgery.
AB - Stem cell research in the field of ophthalmology over the past two decades has advanced knowledge and treatment dramatically. Bone marrow-derived stem cells (BM-MSCs) have been widely studied and have many applications in the eye and other organs; since processed lipoaspirate was first identified as a source of adipose tissue derived stem cells (ASCs), further research has blossomed in this exciting new area. Despite the growth in research involving systemic adipose tissue, the orbital adipose tissue, which is unique in its embryology and has an abundant supply of stem cells, has only recently gained attention. The purpose of this chapter is to outline our current knowledge and recent advances in stem cell research and applications in the orbit, particular orbital adipose stem cells. This chapter will review the fundamentals of adipose stem cell research, the role of orbital fat, dysregulation of orbital adipogenesis, new research on orbital fat stem cells (OFSCs), and potential applications in inflammatory disease and reconstructive and esthetic surgery.
KW - Adipose Stem Cells
KW - Orbital Adipose Tissue
KW - Orbital Fat Stem Cells
KW - Prostaglandin-Associated Periorbitopathy
KW - Thyroid Eye Disease
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U2 - 10.1007/s40135-014-0044-6
DO - 10.1007/s40135-014-0044-6
M3 - Article
AN - SCOPUS:84940830271
VL - 2
SP - 107
EP - 115
JO - Current Ophthalmology Reports
JF - Current Ophthalmology Reports
SN - 2167-4868
IS - 3
ER -