Oral rehydration of infants in a large urban U.S. medical center

Akram M. Tamer, Lawrence B Friedman, Stefan R W Maxwell, Harry A. Cynamon, Hugo N. Perez, William W. Cleveland

Research output: Contribution to journalArticle

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Abstract

A prospective randomized study of 100 well-nourished infants with acute gastroenteritis resulting in dehydration and acidosis was carried out at the Jackson Memorial Hospital, Miami from 1981 to 1983. Patients were randomly assigned to received either standard intravenous therapy or oral rehydration. Infants in the latter group first received solution A containing 75 mEq/L sodium, 30 mEq/L potassium, 75 mEq/L chlorine, 30 mEq/L bicarbonate, and 2 mg/dl glucose. After ad libitum feeding for six hours, solution B containing 50 mEq/L sodium, 30 mEq/L potassium, 50 mEq/L chlorine, 30 mEq/L bicarbonate, and 3 mg/dl glucose was given. With three exceptions (6%), oral rehydration was comparable to the intravenous regimen in clinical estimates of improvement, although the oral group had more stools in the first day. The oral group had faster correction of acidosis and a sustained rise in serum potassium concentration, whereas in the intravenous group the potassium concentration showed first a drop with a later increase, but levels were at all times below those in the oral group. Although potassium was given from the beginning of oral rehydration, and at a higher concentration than recommended by the World Health Organization, no hyperkalemia occurred. We concluded that oral therapy is safe, less expensive for patients, and more convenient for the medical and nursing staffs.

Original languageEnglish
Pages (from-to)14-19
Number of pages6
JournalThe Journal of pediatrics
Volume107
Issue number1
DOIs
StatePublished - Jan 1 1985

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Fluid Therapy
Potassium
Chlorine
Bicarbonates
Acidosis
Sodium
Glucose
Hyperkalemia
Nursing Staff
Medical Staff
Gastroenteritis
Dehydration
Prospective Studies
Serum

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Tamer, A. M., Friedman, L. B., Maxwell, S. R. W., Cynamon, H. A., Perez, H. N., & Cleveland, W. W. (1985). Oral rehydration of infants in a large urban U.S. medical center. The Journal of pediatrics, 107(1), 14-19. https://doi.org/10.1016/S0022-3476(85)80606-5

Oral rehydration of infants in a large urban U.S. medical center. / Tamer, Akram M.; Friedman, Lawrence B; Maxwell, Stefan R W; Cynamon, Harry A.; Perez, Hugo N.; Cleveland, William W.

In: The Journal of pediatrics, Vol. 107, No. 1, 01.01.1985, p. 14-19.

Research output: Contribution to journalArticle

Tamer, AM, Friedman, LB, Maxwell, SRW, Cynamon, HA, Perez, HN & Cleveland, WW 1985, 'Oral rehydration of infants in a large urban U.S. medical center', The Journal of pediatrics, vol. 107, no. 1, pp. 14-19. https://doi.org/10.1016/S0022-3476(85)80606-5
Tamer, Akram M. ; Friedman, Lawrence B ; Maxwell, Stefan R W ; Cynamon, Harry A. ; Perez, Hugo N. ; Cleveland, William W. / Oral rehydration of infants in a large urban U.S. medical center. In: The Journal of pediatrics. 1985 ; Vol. 107, No. 1. pp. 14-19.
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