Oral manifestations of Darter's disease: A clinical and pathological study

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Patients with Darier's disease may present oral lesions which occur in about 50% of affected patients. The palate, gingiva, buccal mucosa and the tongue are most commonly affected. This study reports the clinical and pathological features of me oral manifestations of Darier's disease. The pathology of early reddish spots reveals ortho-parakeratotic hyperkeratosis with focal hypergranulosis ancl acanthosis. The pathology or established white papules shows the typical features of acantholytic dyskeratosis with suprabasal clefts containing acantholytic ayskeratotic keratinocytes. Our study indicates that although acantholytic dyskeratosis is a pathological marker or established oral lesions of Darier's disease, this pathological feature may not be detectable in early oral spots. The absence of acantholytic dyskeratosis in early lesions is not exclusive to mouth pathology, it has been described in the early nail lesions of patients with Darier's disease. These findings indicate that the absence of acantholytic dyskeratosis should not be considered an absolute criterion for excluding a possible diagnosis of Darier's disease.

Original languageEnglish
Pages (from-to)23-25
Number of pages3
JournalEuropean Journal of Dermatology
Volume6
Issue number1
StatePublished - Dec 1 1996
Externally publishedYes

Fingerprint

Darier Disease
Oral Manifestations
Pathology
Palate
Mouth Mucosa
Gingiva
Nails
Keratinocytes
Tongue
Mouth
Clinical Studies

Keywords

  • Acantholytic dyskeratosis
  • Darier's disease
  • Mouth
  • Oral pathology

ASJC Scopus subject areas

  • Dermatology

Cite this

Oral manifestations of Darter's disease : A clinical and pathological study. / Tosti, Antonella.

In: European Journal of Dermatology, Vol. 6, No. 1, 01.12.1996, p. 23-25.

Research output: Contribution to journalArticle

@article{5bd0dbe95a7d4dc7b5e82b8ef791ad0a,
title = "Oral manifestations of Darter's disease: A clinical and pathological study",
abstract = "Patients with Darier's disease may present oral lesions which occur in about 50{\%} of affected patients. The palate, gingiva, buccal mucosa and the tongue are most commonly affected. This study reports the clinical and pathological features of me oral manifestations of Darier's disease. The pathology of early reddish spots reveals ortho-parakeratotic hyperkeratosis with focal hypergranulosis ancl acanthosis. The pathology or established white papules shows the typical features of acantholytic dyskeratosis with suprabasal clefts containing acantholytic ayskeratotic keratinocytes. Our study indicates that although acantholytic dyskeratosis is a pathological marker or established oral lesions of Darier's disease, this pathological feature may not be detectable in early oral spots. The absence of acantholytic dyskeratosis in early lesions is not exclusive to mouth pathology, it has been described in the early nail lesions of patients with Darier's disease. These findings indicate that the absence of acantholytic dyskeratosis should not be considered an absolute criterion for excluding a possible diagnosis of Darier's disease.",
keywords = "Acantholytic dyskeratosis, Darier's disease, Mouth, Oral pathology",
author = "Antonella Tosti",
year = "1996",
month = "12",
day = "1",
language = "English",
volume = "6",
pages = "23--25",
journal = "European Journal of Dermatology",
issn = "1167-1122",
publisher = "John Libbey Eurotext",
number = "1",

}

TY - JOUR

T1 - Oral manifestations of Darter's disease

T2 - A clinical and pathological study

AU - Tosti, Antonella

PY - 1996/12/1

Y1 - 1996/12/1

N2 - Patients with Darier's disease may present oral lesions which occur in about 50% of affected patients. The palate, gingiva, buccal mucosa and the tongue are most commonly affected. This study reports the clinical and pathological features of me oral manifestations of Darier's disease. The pathology of early reddish spots reveals ortho-parakeratotic hyperkeratosis with focal hypergranulosis ancl acanthosis. The pathology or established white papules shows the typical features of acantholytic dyskeratosis with suprabasal clefts containing acantholytic ayskeratotic keratinocytes. Our study indicates that although acantholytic dyskeratosis is a pathological marker or established oral lesions of Darier's disease, this pathological feature may not be detectable in early oral spots. The absence of acantholytic dyskeratosis in early lesions is not exclusive to mouth pathology, it has been described in the early nail lesions of patients with Darier's disease. These findings indicate that the absence of acantholytic dyskeratosis should not be considered an absolute criterion for excluding a possible diagnosis of Darier's disease.

AB - Patients with Darier's disease may present oral lesions which occur in about 50% of affected patients. The palate, gingiva, buccal mucosa and the tongue are most commonly affected. This study reports the clinical and pathological features of me oral manifestations of Darier's disease. The pathology of early reddish spots reveals ortho-parakeratotic hyperkeratosis with focal hypergranulosis ancl acanthosis. The pathology or established white papules shows the typical features of acantholytic dyskeratosis with suprabasal clefts containing acantholytic ayskeratotic keratinocytes. Our study indicates that although acantholytic dyskeratosis is a pathological marker or established oral lesions of Darier's disease, this pathological feature may not be detectable in early oral spots. The absence of acantholytic dyskeratosis in early lesions is not exclusive to mouth pathology, it has been described in the early nail lesions of patients with Darier's disease. These findings indicate that the absence of acantholytic dyskeratosis should not be considered an absolute criterion for excluding a possible diagnosis of Darier's disease.

KW - Acantholytic dyskeratosis

KW - Darier's disease

KW - Mouth

KW - Oral pathology

UR - http://www.scopus.com/inward/record.url?scp=0030044050&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0030044050&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:0030044050

VL - 6

SP - 23

EP - 25

JO - European Journal of Dermatology

JF - European Journal of Dermatology

SN - 1167-1122

IS - 1

ER -